HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?

Omics : a Journal of Integrative Biology
Rutendo B L Zinyama-GutsireTakafira Mduluza

Abstract

HIV infection remains a major global health burden since its discovery in 1983. Sub-Saharan Africa is the region hardest hit by the HIV/AIDS pandemic where 63% of the 33 million infected people live. While there is marked person-to-person variability in susceptibility, progression, and survival with HIV infection, there is a paucity of predictive diagnostics associated with these clinical endpoints. In this regard, the deficiency in plasma Mannose Binding Lectin (MBL) is a common opsonic defect reported to increase susceptibility infections, including HIV. To the best of our knowledge, we report here the first study on the putative role of MBL deficiency on HIV progression and survival in an African adult population. We hypothesized that MBL deficiency has a role to play in HIV infection by increasing HIV disease progression and decreasing survival. We assessed the role of MBL deficiency on HIV disease progression and survival in a Zimbabwean adult population enrolled in the Mupfure Schistosomiasis and HIV (MUSH) cohort. We analyzed blood samples for MBL levels, MBL2 genotypes, HIV-1 status, viral load, and CD4(+) T cell counts. Participants were followed for 3 years wherein the endpoints were measured at baseline, 6 weeks, and...Continue Reading

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Citations

Jun 18, 2016·Omics : a Journal of Integrative Biology·Rutendo B L Zinyama-GutsireCharles Chasela
Nov 30, 2018·Retrovirology·Viviane Martha Santos de MoraisMaria Rosângela Cunha Duarte Coêlho
Jan 5, 2019·BMC Immunology·Viviane Martha Santos de MoraisMaria Rosângela Cunha Duarte Coêlho

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SHEsis
Stata
COHERE

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