HIV-1 envelope diversity 1 year after seroconversion predicts subsequent disease progression

AIDS
Andrea RachingerAngélique B van 't Wout

Abstract

Recent studies have suggested that the dynamics of HIV-1 evolutionary rate reflect the rate of disease progression. We wished to determine whether viral diversity early in infection is predictive of the subsequent disease course. HIV-1 envelope diversity at seroconversion and 1 year thereafter from 89 homosexual participants of the Amsterdam Cohort Studies on HIV infection and AIDS was correlated with clinical endpoints and markers of disease progression. Heteroduplex mobility assay (HMA) and sequencing followed by calculation of pairwise genetic distances were applied to determine HIV-1 envelope diversity. The HMA pattern (presence or absence of heteroduplexes) and sequence diversity were each tested for correlation with the clinical course of infection. HMA pattern at 1-year postseroconversion was significantly associated with progression to AIDS and AIDS-related death, with presence of heteroduplexes associated with accelerated disease progression. Moreover, not only this dichotomous measure of viral diversity (absence or presence of heteroduplexes), but also genetic diversity itself was associated with disease course. HMA pattern was an independent predictor of accelerated disease progression, also when CCR5 genotype, human...Continue Reading

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Apr 7, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea RachingerAngélique B van 't Wout

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Citations

May 24, 2013·Current Opinion in HIV and AIDS·Caroline A Sabin, Jens D Lundgren
Sep 3, 2013·Journal of Virological Methods·Raj Shankarappa, James I Mullins
May 29, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Thomas Neß
Dec 8, 2017·Journal of Virology·María PernasEzequiel Ruiz-Mateos

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