HIV-1 fitness and macrophages

Journal of Leukocyte Biology
Maureen M GoodenowJohn W Sleasman

Abstract

HIV-1 comprises a collection of closely related, but not identical, viruses or quasispecies. Fitness represents a selective advantage for propagation among populations of organisms competing in a particular environment and is an important characteristic of viruses because of a link between fitness and pathogenesis. Environmental differences based on the type of cell that is targeted for infection or the cell type that produces virus, impact fitness. CD4-expressing cells of lymphocyte or macrophage lineage are the principal host cells for HIV-1, although the milieu in lymphocytes is distinct from the macrophage environment from the perspective of cell half-life and activation, signal transduction and expression of coreceptors, and bioavailability of antiretroviral drugs. Multiple viral determinants, including entry via envelope glycoproteins, replication by reverse transcriptase, and virion maturation by protease activity, contribute to fitness in different cells and provide targets for current antiretroviral therapies. This review focuses on fitness of HIV-1 in macrophages and examines the impact of protease inhibitors on fitness of quasispecies and an unexplained discordance between fitness and pathogenesis.

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Citations

Mar 7, 2007·Current HIV/AIDS Reports·Kenneth R HenryEric J Arts
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sylvia HartmannMartin-Leo Hansmann
Dec 22, 2010·AIDS·Rebecca R GrayMaureen M Goodenow
Oct 14, 2004·Journal of Virology·Carter R CoberleyMaureen M Goodenow
Dec 3, 2008·PloS One·Joseph N BrownMaureen M Goodenow
Dec 14, 2011·Viruses·Christopher J A Duncan, Quentin J Sattentau
Dec 26, 2015·Developmental and Comparative Immunology·Leon Grayfer, Jacques Robert
Sep 10, 2003·Journal of Leukocyte Biology·Ronald G CollmanLuis J Montaner
Jun 9, 2005·Reviews in Medical Virology·Tim van Opijnen, Ben Berkhout
Mar 16, 2007·Clinical Pharmacology and Therapeutics·S R VlahakisA D Badley
Jul 1, 2006·Expert Review of Clinical Immunology·Stephanie Venzke, Oliver T Keppler

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