PMID: 9186784Jan 1, 1997Paper

HIV-1 gp120: a novel viral B cell superantigen

International Reviews of Immunology
J Townsley-FuchsL Goodglick

Abstract

The envelope glycoprotein of the human immunodeficiency virus (HIV-1), gp120, has recently been characterized as a novel immunoglobulin superantigen (Ig-SAg) [1,2]. Analogous to the interaction of SAgs with T cells, gp120 binds to an unusually large proportion of immunoglobulins (lgs) from HIV-uninfected individuals; most, if not all of these Igs are members of the VH3 family [3]. Functionally, gp120 preferentially stimulates VH3 B cells in vitro. This stimulation correlates with an in vivo VH3 activation during HIV infection. Curiously, this initial activation is followed by a subsequent depletion of VH3-expressing B cells as individuals progress to AIDS. In this article we will review our current understanding of the superantigenic properties of HIV gp120. Specifically we will focus on structural aspects of the binding interaction. on the ontological development of these superantigen-binding antibodies, and on potential roles that this unconventional Ig-pathogen interaction might play in the pathogenesis of HIV-induced disease.

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Citations

May 6, 2003·Veterinary Immunology and Immunopathology·Kuang-Wen LiaoRea-Min Chu
Mar 7, 2009·The Journal of Infectious Diseases·Steven P O'HaraNicholas F Larusso
Sep 24, 2010·BMC Infectious Diseases·Herbert LongweNeil French
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Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Georg W Bornkamm
Jul 15, 2005·Annals of the New York Academy of Sciences·Nattawat OnlamoonAftab A Ansari
Jun 26, 2002·Viral Immunology·Xueling Wu, Susan Jackson
Oct 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy P Y ChungJohn P Moore
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ronald W ScamurraEdward N Janoff
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter I LoboJennifer A White
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R W ScamurraE N Janoff
Jun 3, 2018·The Journal of Biological Chemistry·Paul Barlow
Mar 1, 2019·International Journal of STD & AIDS·Miguel AlpalhãoPaulo Filipe
Aug 1, 1997·Immunology Today·G J Silverman

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