HIV-1 gp120 and immune network

International Reviews of Immunology
R Metlas, V Veljkovic

Abstract

It has been demonstrated that the immunodominant V3 loop of HIV-1 gp120 and its flanking regions bear sequence and structural homology to the framework and complementarity-determining regions of human immunoglobulins. It has been proposed that the Ig-like domain of gp120 might encode idiotypes and in this way permit HIV-1 entry into the immune regulatory network. This notion is strongly supported by results demonstrating that the anti-V3 loop and anti-Ig antibodies of healthy individuals share complementary structure and that V3 reactive antibodies are present in HIV-negative sera. This might be the mechanism by which HIV induces immunological abnormalities, and it should be taken into consideration in AIDS vaccine development.

References

Nov 13, 1992·Science·E J Fuchs, P Matzinger
Sep 1, 1992·AIDS Research and Human Retroviruses·P CordialiV Colizzi
Jan 1, 1992·International Reviews of Immunology·S MüllerG J Silverman
Jun 1, 1992·Immunology Today·J HabeshawA Dalgleish
Jan 1, 1992·Vox Sanguinis·C SüsalG Opelz
Jan 1, 1992·Immunology Today·V Veljković, R Metlas
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KarpatkinY H Kouri
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G W HoffmannM D Grant
Apr 1, 1991·Immunology Today·I R Cohen, D B Young
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Weiss, B Bogen
May 26, 1989·Science·J L Strominger
Aug 1, 1989·Immunological Reviews·A Coutinho
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I LundkvistD Holmberg
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K JavaherianS D Putney
Dec 1, 1986·Clinical Immunology and Immunopathology·J L Ziegler, D P Stites
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A Kupfer, S J Singer
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T Tokuhisa, K Rajewsky
Aug 1, 1985·European Journal of Immunology·M A ValentineD A Carson
Jan 1, 1986·Advances in Immunology·R W Chesnut, H M Grey
Jan 1, 1983·Annual Review of Immunology·K Rajewsky, T Takemori
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·D F LakeJ J Marchalonis
Nov 15, 1993·Biochemical and Biophysical Research Communications·V VelikovićS Pongor
May 1, 1993·AIDS Research and Human Retroviruses·D H Katz
May 20, 1999·AIDS Research and Human Retroviruses·R MetlasA Colombatti
Jul 31, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R MetlasA Colombatti
Oct 22, 1971·Nature·G Taylor

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Citations

Jan 1, 2008·Vaccine·Veljko VeljkovicMae-Wan Ho
Jun 23, 2009·Scandinavian Journal of Medicine & Science in Sports·M VeljkovicM Dopsaj

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