HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2)

Biochemical and Biophysical Research Communications
G BagettaA Finazzi-Agrò

Abstract

The effect of subchronic intracerebroventricular (i.c.v.) injection of the human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120 (100 ng, given daily for up to 7 consecutive days) on cyclooxygenase type 2 (COX-2) expression was studied by immunohistochemistry in the brain of adult rats. In comparison to control, bovine serum albumin (100 ng, given i.c.v. for up to 7 days) treated animals (n = 6), a single daily injection of the viral protein for 7 consecutive days enhanced the number of COX-2 immunoreactive cells in the brain cortex of rats (n = 6 per group) and this was accompanied by a 50% increase over control PGE2 content in whole brain tissue homogenates (n = 6). In another series of experiments, pretreatment of rats (n = 6) with indomethacin (6.0 mg/kg given i.p. 1 h before gp120 injection), an inhibitor COX activity, prevented apoptotic death typically produced by gp120 in the neocortex of rat suggesting that enhancement of COX-2 expression may be involved in the mechanisms of apoptosis yielded by the HIV-1 coat protein.

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Citations

Oct 19, 2006·Journal of Biomedicine & Biotechnology·David R Wallace
Oct 12, 2000·Journal of Neuroimmunology·H J Schluesener, K Seid
Apr 9, 2002·Prostaglandins & Other Lipid Mediators·Nannan ChenCarol Shoshkes Reiss
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Jan 1, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Khanh vinh quốc L Ng, Lan Thi Hoàng Nguyễn
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Jan 1, 2008·Biomarker Insights·Anja-Kristina BrustFranz H Grus
Jun 21, 2001·Biochemical and Biophysical Research Communications·A ZafiropoulosE Krambovitis

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis