PMID: 7523014Nov 1, 1994Paper

HIV-1 gp160 as a modifier of Th1 and Th2 cytokine response: gp160 suppresses interferon-gamma and interleukin-2 production concomitantly with enhanced interleukin-4 production in vitro

Clinical Immunology and Immunopathology
R HuS Pahwa

Abstract

Disease progression in HIV-1 infection is reported to be associated with a gradual shift in CD4+ T cell function from a Th type 1 to a Th type 2 of response, but the underlying mechanism remains unclear. In this study, the effect of HIV-1 envelope glycoprotein gp160 on secretion of cytokines IFN-gamma/IL-2 (Th1 type) and IL-4 (Th2 type) was analyzed using freshly isolated unfractioned peripheral blood mononuclear cells (PBMC), CD4+ T cell lines, and PBMC depleted of CD8+ cells (CD8- PBMC) as target cells. Pretreatment of these cells with HIV gp160 significantly reduced PHA-induced secretion of IFN-gamma and IL-2 but augmented IL-4 production. This effect of gp160 was not observed when the target cells consisted of PBMC depleted of either CD4+ cells (CD4- PBMC) or of CD2+ cells (CD2- PBMC). Pretreatment of gp160 with soluble CD4-immunoglobulin chimeric molecules abrogated the observed effects of gp160, suggesting that CD4-gp120 interaction is required for modification of the cytokine secretion profile. Our results suggest that exposure of CD4+ T cells to HIV-1 envelope proteins may modify the responses evoked by additional stimuli in favor of a Th2-type dominant response.

Citations

May 14, 1999·Parasitology Today·D WoldayS Britton
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J DesbaratsM K Newell
Dec 2, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J E LeighP L Fidel
Jan 1, 2005·Journal of the International AIDS Society·Brian M JonesYu-Lung Lau
Sep 10, 2003·Antiviral Chemistry & Chemotherapy·K Kedzierska, S M Crowe
Aug 17, 2006·Journal of Leukocyte Biology·Claire Chougnet, Sandra Gessani
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten U VogelDavid I Watkins

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