HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

The EMBO Journal
P D BieniaszB R Cullen

Abstract

Although the human hCCR-5 chemokine receptor can serve as a co-receptor for both M-tropic (ADA and BaL) and dual-tropic (89.6) strains of human immunodeficiency virus type 1 (HIV-1), the closely related mouse mCCR-5 homolog is inactive. We used chimeric hCCR-5-mCCR-5 receptor molecules to examine the functional importance of the three extracellular domains of hCCR-5 that differ in sequence from their mCCR-5 equivalents. While this analysis revealed that all three of these extracellular domains could participate in the functional interaction with HIV-1 envelope, clear differences were observed when different HIV-1 strains were analyzed. Thus, while the ADA HIV-1 isolate could effectively utilize chimeric human-mouse CCR-5 chimeras containing any single human extracellular domain, the BaL isolate required any two human extracellular sequences while the 89.6 isolate would only interact effectively with chimeras containing all three human extracellular sequences. Further analysis using hybrid HIV-1 envelope proteins showed that the difference in co-receptor specificity displayed by the ADA and BaL isolates was due partly to a single amino acid change in the V3 loop, although this interaction was clearly also modulated by other enve...Continue Reading

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P WesterveltL Ratner
Jul 11, 1986·Science·S GartnerM Popovic
Jul 1, 1984·Cell·I A WilsonR A Lerner
Jan 1, 1994·Annual Review of Immunology·P M Murphy
Oct 31, 1996·Nature·L ZhangD D Ho

❮ Previous
Next ❯

Citations

Dec 30, 1998·Archives of Pharmacal Research·H Choe
May 25, 2006·Journal of Molecular Modeling·Kelby B NapierJohn O Trent
Nov 1, 2002·Biochemical and Biophysical Research Communications·Stavroula BaritakiElias Krambovitis
Aug 1, 1997·Current Opinion in Immunology·J P MooreT Dragic
Dec 17, 2002·Current Opinion in Biotechnology·Camille Haslin, Jean Claude Chermann
Jun 6, 2003·Bioorganic & Medicinal Chemistry·Wieslaw KazmierskiTerry Kenakin
Nov 17, 2011·Journal of Medicinal Chemistry·Won-Tak ChoiJing An
Aug 21, 2002·The Journal of Experimental Medicine·Jason A LaBonteJoseph Sodroski
Jul 13, 2000·AIDS Research and Human Retroviruses·M BabaK Okonogi
Dec 16, 2000·AIDS Research and Human Retroviruses·U EsserM A Goldsmith
Aug 4, 2001·AIDS Research and Human Retroviruses·Z LiaoJ E Hildreth
Jun 5, 1999·AIDS Research and Human Retroviruses·F VerrierM Girard
Jan 9, 2010·AIDS Research and Human Retroviruses·John C TiltonRobert W Doms
Sep 10, 2002·AIDS·Julio Martín-GarcíaFrancisco González-Scarano
Sep 3, 2009·AIDS·Pierre Corbeau, Jacques Reynes
Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Masao NishikawaJun-Ichi Fujisawa
Oct 12, 2000·Journal of Virology·P D Bieniasz, B R Cullen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.