HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling

Cardiovascular Toxicology
Milan FialaJames Arthos

Abstract

We examined heart tissues of AIDS patients with or without HIV cardiomyopathy (HIVCM) by immunohistochemistry, in situ polymerase chain reaction, in situ riboprobe hybridization, and the TUNEL technique for apoptosis. In HIVCM tissues, only inflammatory cells, but not endothelial cells or cardiomyocytes, displayed HIV-1 DNA and RNA. However, macrophages, lymphocytes, and--in a patchy fashion--cardiomyocytes and endothelial cells exhibited virus envelope protein gp120. Macrophages infiltrated the myocardium in a perivascular fashion and expressed tumor necrosis factor family ligands; adjacent cardiomyocytes suffered apoptosis. In vitro HIV-1 strongly invaded neonatal rat ventricular myocytes (NRVMs) and coronary artery endothelial cells (CAECs) and induced microvilli but did not replicate. HIV-1, gp120, or Tat induced Erk 1/2 phosphorylation, activation of caspase-3, and apoptosis of NRVMs and CAECs; all of these were inhibited by a MAPK/ERK-kinase (MEK) inhibitor U0126. The pathogenesis of HIVCM involves HIV-1 replication in inflammatory cells and induction of cardiomyocyte apoptosis by (1) the extrinsic pathway through apoptotic ligands and (2) the intrinsic pathway through direct virus entry and gp120- and Tat-proapoptotic si...Continue Reading

Citations

Oct 19, 2007·Cardiovascular Toxicology·Enkhsaikhan PurevjavNeil E Bowles
Oct 14, 2008·Cardiovascular Toxicology·Youxi YuanMitchell S Finkel
Apr 2, 2009·Cardiovascular Toxicology·Qiujuan FangMitchell S Finkel
Aug 1, 2009·Cardiovascular Toxicology·Chalak BerzingiMitchell S Finkel
Aug 20, 2010·Cardiovascular Toxicology·Kathleen H McDonoughOm Prakash
Apr 9, 2008·Chemical Research in Toxicology·James J KohlerWilliam Lewis
Apr 12, 2013·AIDS Research and Human Retroviruses·William Todd CadeKevin E Yarasheski
Jul 12, 2012·AIDS·Kunjal PatelUNKNOWN International Maternal Pediatric Adolescent AIDS Clinical Trials 219219C Study Team
Aug 21, 2008·Biological Chemistry·Stephan Pleschka
Feb 18, 2016·BioMed Research International·Rebecca H Lumsden, Gerald S Bloomfield
Oct 27, 2011·European Journal of Immunology·Yi-Qun KuangDenis J Dupré
Aug 8, 2015·JACC. Heart Failure·Gerald S BloomfieldEric J Velazquez
Aug 4, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ting WangMatthias Clauss
Jul 17, 2012·International Journal of Cardiology·Liang MengGuoxian Qi
Mar 6, 2007·International Journal of Cardiology·Jean-Jacques MonsuezDaniel Vittecoq
Mar 16, 2018·Current Opinion in Cardiology·Mark N Belkin, Nir Uriel
Dec 12, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yung-Feng YenChung-Yeh Deng
Apr 23, 2011·Expert Review of Respiratory Medicine·Stefania CicaliniNicola Petrosillo
Apr 13, 2012·AIDS·Fangping ChenMitchell S Finkel
Oct 18, 2019·JCI Insight·Daniel BraysonCatherine M Shanahan
Jan 1, 2015·Journal of the International AIDS Society·Mary-Ann DaviesMarlène Bras
Dec 8, 2015·Journal of the International AIDS Society·Rachel C VreemanWinstone M Nyandiko
Mar 12, 2020·Frontiers in Cellular and Infection Microbiology·David Ajasin, Eliseo A Eugenin
May 5, 2012·Journal of Applied Physiology·Fangping ChenMitchell S Finkel
May 12, 2017·Journal of Cellular Physiology·Farzaneh G TahrirKamel Khalili
Aug 19, 2017·Scientific Reports·Manish K GuptaKamel Khalili
Sep 27, 2018·Journal of Cellular Physiology·Joseph Y CheungArthur M Feldman
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Appakkudal R AnandDurgadevi Parthasarathy
Feb 24, 2021·Heart Failure Reviews·Harry ChoiHani Jneid
Jan 26, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yuqing ChenFrank Qian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis