HIV-1 Infection and Type 1 Interferon: Navigating Through Uncertain Waters

AIDS Research and Human Retroviruses
Sho SugawaraAshwin Balagopal

Abstract

HIV-1 remains a chronic viral infection of global health importance. Although HIV-1 replication can be controlled by antiretroviral therapy (ART), there is no cure due to persistence of a long-lived latent reservoir. In addition, people living with HIV-1 who are taking ART still bear signatures of persistent immune activation that include continued type 1 interferon (IFN) signaling. Paradoxically, type 1 IFN exerts a limited role on the control of chronic HIV-1. Indeed, recent reports from humanized mice suggest that type 1 IFN may partly maintain the latent reservoir. In this review, we discuss the molecular interactions between HIV-1 and the type 1 IFN signaling pathway, and examine the efficacy of type 1 IFNs in vivo. We also explore whether limited type 1 IFN manipulation may have a therapeutic role.

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Sep 28, 2018·Viral Immunology·Victoria E Thaney, Marcus Kaul
Nov 24, 2020·Frontiers in Immunology·Wilfried PoschDoris Wilflingseder
Aug 23, 2020·EBioMedicine·Leila B GironMohamed Abdel-Mohsen
May 14, 2021·Journal of Virology·Alexandra TauzinFabrizio Mammano
Sep 10, 2021·Wiley Interdisciplinary Reviews. RNA·Joanna GrochowskaRoman J Szczesny
Jan 12, 2022·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stefano RinaldiSavita Pahwa

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BETA
nuclear translocation
ubiquitination

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