PMID: 2098151Sep 1, 1990Paper

HIV-1 infection in HIV-1 enzyme-linked immunoassay seronegative patients in Kinshasa, Zaire

International Journal of STD & AIDS
R ColebundersP Piot

Abstract

Serum samples of 62 African patients who had clinical manifestations of HIV-1 infection but were seronegative for HIV-1 by ELISA (Organon) were subsequently further tested by another HIV-1 ELISA test (Wellcozyme), HIV-1 IgG Western blot, HIV-1 antigen detection and HIV-2 ELISA. Patients' lymphocytes were cultured for HIV-1 and 2. Because of limited quantities of serum available all tests were not performed on all samples. Seven (26%) of 27 sera of patients meeting the WHO clinical case definition of AIDS were Western-blot-positive. In contrast, of 35 patients' sera with possible HIV related disease, only one (3%) was Western blot positive (P = 0.02) and none of 75 sera from HIV-1 ELISA (Organon) seronegative blood donors (P less than 0.01) were Western blot positive. Of 30 HIV-1 ELISA (Organon) seronegative patients tested with the HIV-1 ELISA Wellcozyme assay only one was seropositive (this patient's serum was also Western blot positive). Of 17 HIV-1 ELISA (Organon) seronegative patients tested, HIV-1 antigen was found in 1 case (6%) (this patient's serum was Western blot negative). None of the 34 patients tested by HIV-2 serology was HIV-2 seropositive. HIV-1 was isolated by culture in 3 (21%) of 14 HIV-1 ELISA seronegative p...Continue Reading

References

Feb 1, 1986·Annals of Internal Medicine·K H MayerJ E Groopman
Feb 1, 1988·The Journal of Infectious Diseases·R ColebundersP Piot
May 7, 1987·The New England Journal of Medicine·F ClavelL Montagnier
Jun 1, 1987·The Journal of Infectious Diseases·D A CooperR Penny
Oct 2, 1986·The New England Journal of Medicine·M C Bach, J A Boothby
Dec 22, 1984·Lancet·S Z SalahuddinR C Gallo

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Citations

May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramandeep KaurDinesh Kumar

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