HIV-1 infection of first-trimester and term human placental tissue: a possible mode of maternal-fetal transmission.

The Journal of Infectious Diseases
W MauryA B Rabson

Abstract

To understand the potential role of placental tissue in the pathogenesis of neonatal AIDS, the distribution of human immunodeficiency virus type 1 (HIV-1) receptor and the infectability of placental tissue by HIV-1 were studied. Both the mRNA and the protein for the HIV receptor (CD4) were present in fetal-derived placenta. By immunofluorescent microscopy, a number of different cell types appeared to be CD4+; positive cells were observed in the lining and stroma of the chorionic villi. Some of these CD4+ cells dual-labeled with the trophoblastic marker placental lactogen. In addition, CD4+ cells were observed within the lining of placental blood vessels. Organ cultures of first-trimester and term placentas were infectable by HIV as monitored by reverse transcriptase activity of culture supernatants and by immunofluorescent labeling of HIV antigens. One potential route of congenital HIV transmission may be direct placental infection by HIV as early as the first trimester, with subsequent transplacental spread of the virus.

Citations

Jul 1, 1996·Journal of Biomedical Science·N. Ahmad
Mar 1, 1993·Journal of Nurse-midwifery·E De FerrariJ R Anderson
May 4, 2001·Journal of Reproductive Immunology·I AthanassakisS Vassiliadis
Mar 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·J Y Mok
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D H SchwartzK Blakemore
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A BácsiF D Tóth
Jun 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A S BourinbaiarS Lee-Huang
May 1, 1997·Obstetrical & Gynecological Survey·A van Vliet, J van Roosmalen
Jul 17, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J LadnerF Dabis
Jan 1, 1995·Paediatric and Perinatal Epidemiology·L Kuhn, Z A Stein
Feb 1, 1994·Journal of Medical Primatology·T G GolosK T Schultz
Nov 17, 2010·Clinics in Perinatology·Barb Lohman-PayneSarah L Rowland-Jones
Nov 1, 1992·Annals of Epidemiology·S H VermundR A Kaslow
Jan 1, 1991·Current Problems in Pediatrics·S T Shulman
Mar 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·F D Johnstone
May 10, 2013·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·William Ackerman, Jesse J Kwiek
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Xue-Ping WangJing-Xia Zhang
Mar 19, 2004·Revista do Hospital das Clínicas·Patrícia El BeituneErnesto Antônio Figueiró-Filho
Jul 1, 1993·The American Journal of Medicine·J A Levy
Apr 1, 1990·AIDS Research and Human Retroviruses·P A FurthL Hennighausen
Sep 1, 1991·AIDS Research and Human Retroviruses·G C DouglasB F King
Aug 1, 1995·AIDS Research and Human Retroviruses·T BuiR J Ho
Mar 1, 1991·AIDS Research and Human Retroviruses·V CourgnaudC Bréchot
Sep 1, 1992·AIDS Research and Human Retroviruses·M E LafonA Kirn
Feb 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M TemmermanP Piot
Oct 29, 1993·Annals of the New York Academy of Sciences·V V Joshi
Jun 2, 2007·Reviews in Medical Virology·Dara A Lehman, Carey Farquhar
Aug 24, 1999·Journal of Acquired Immune Deficiency Syndromes : JAIDS·B BaccettiP Piomboni
Apr 1, 1992·Clinical and Experimental Immunology·F J DavidG Chaouat
Jan 1, 1995·Cadernos de saúde pública·M B Ortigão
Nov 1, 1992·International Journal of STD & AIDS·M TemmermanP Piot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.