HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

Nature Medicine
Holly JanesMorgane Rolland

Abstract

Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.

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Citations

Feb 14, 2018·Bioinformatics·Sung Yong ParkHa Youn Lee
Dec 15, 2015·Current Opinion in Infectious Diseases·Godelieve J de Bree, Rebecca M Lynch
Dec 4, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mariya V SivaySusan H Eshleman
Feb 23, 2020·PLoS Computational Biology·Daniel B ReevesJoshua T Schiffer
May 18, 2016·Nature Medicine·Jonathan M CarlsonPaul A Goepfert
Feb 11, 2020·Frontiers in Microbiology·Yu ZhangLin Li
Nov 18, 2016·Royal Society Open Science·Sean Nee
Jun 30, 2021·Journal of the Royal Society, Interface·Daniel B ReevesBryan T Mayer

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Methods Mentioned

BETA
PCR
circumcision

Clinical Trials Mentioned

NCT00095576
NCT00223080

Software Mentioned

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