HIV-1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Maria Giovanna QuarantaMarina Viora

Abstract

The accessory HIV-1 Nef protein is a crucial determinant for viral replication and pathogenesis. During HIV infection, loss of immune control in the setting of a strong and broad HIV-specific T-lymphocyte response, leads to a lethal outcome through AIDS. Moreover, dysfunction of dendritic cells (DCs) may contribute to the immune suppression associated with AIDS progression. We recently demonstrated that exogenous Nef selectively activates immature DCs manipulating their phenotypical, morphological, and functional developmental program. Here, we tracked whether Nef, targeting DCs, could be involved in the dysregulation of CD8+ T cell responses. We found that Nef inhibits the capacity of DCs to prime alloreactive CD8+ T cell responses down-regulating their proliferation and functional competence. This coincides with the induction of CD8+ T cell apoptosis. Nef oversees apoptotic killing of CD8+ T cells up-regulating TNF-alpha and FasL production by DCs and interfering with the death receptor pathway in CD8+ T cells and thus activating caspase 8. Our findings suggest that Nef may contribute to the immune evasion associated with HIV-1 infection, subverting DC biology. This may help explain the pleiotropic function that Nef plays dur...Continue Reading

References

Sep 1, 1992·Clinical and Experimental Immunology·A KalinkovichZ Bentwich
Jul 23, 1987·Nature·B D WalkerR T Schooley
Dec 1, 1995·The Journal of Experimental Medicine·N KayagakiH Yagita
Apr 1, 1996·The Journal of Experimental Medicine·G Süss, K Shortman
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·A AmendolaM Piacentini
Feb 25, 1998·Journal of Clinical Immunology·M BoirivantO Pugliese
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jun 17, 1998·The Journal of Clinical Investigation·D H DockrellC V Paya
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Aug 28, 1998·Science·D R Green, J C Reed
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L ContiS Gessani
Mar 10, 2001·Nature·P ChampagneG Pantaleo
Jan 5, 2002·Immunity·Y M MuellerP D Katsikis
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ganwei LuNikola L Vujanovic
Apr 24, 2002·Experimental Cell Research·Maria Giovanna QuarantaMarina Viora
Apr 24, 2002·Immunity·Oliver T Fackler, Andreas S Baur
Jun 29, 2002·Current Opinion in Immunology·Judy LiebermanPremlata Shankar
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davorka MessmerMelissa Pope

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Citations

Dec 21, 2004·Springer Seminars in Immunopathology·Marie Larsson
Apr 10, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shahram Salek-Ardakani, Michael Croft
Oct 21, 2011·Journal of Virology·Anke HeigeleFrank Kirchhoff
Sep 8, 2010·Pharmacology & Therapeutics·Simona FiorentiniArnaldo Caruso
Nov 23, 2013·Trends in Immunology·Jurjen TelI Jolanda M de Vries
May 19, 2009·BioFactors·Maria Giovanna QuarantaMarina Viora
May 11, 2010·European Journal of Immunology·Karlhans F CheMarie Larsson
Dec 1, 2009·Viruses·Esperanza Gómez-LucíaAna Doménech
Oct 6, 2005·Journal of Leukocyte Biology·Alexandre IannelloAli Ahmad
Apr 14, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Giovanna QuarantaMarina Viora
Apr 19, 2013·AIDS·Sylvie AmuFrancesca Chiodi
Nov 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Giovanna QuarantaMarina Viora
Oct 13, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dieter HoffmannVolker Erfle
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jelena MannMark Harris

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