HIV-1 proteins dysregulate motivational processes and dopamine circuitry

Scientific Reports
Sarah J BertrandRosemarie M Booze

Abstract

Motivational alterations, such as apathy, in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 transgenic (Tg) rat to assess effect of long-term HIV-1 protein exposure on motivated behavior using sucrose (1-30%, w/v) and cocaine (0.01-1.0 mg/kg/infusion) maintained responding with fixed-ratio (FR) and progressive-ratio (PR) schedules of reinforcement. For sucrose-reinforced responding, HIV-1 Tg rats displayed no change in EC50 relative to controls, suggesting no change in sucrose reinforcement but had a downward shifted concentration-response curves, suggesting a decrease in response vigor. Cocaine-maintained responding was attenuated in HIV-1 Tg rats (FR1 0.33 mg/kg/infusion and PR 1.0 mg/kg/infusion). Dose-response tests (PR) revealed that HIV-1 Tg animals responded significantly less than F344 control rats and failed to earn significantly more infusions of cocaine as the unit dose increased. When choosing between cocaine and sucrose, control rats initially chose sucrose but with time shifted to a cocaine preference. In contrast, HIV-1 disrupted choice behaviors. DAT function was altered in the striatum of HIV-1 Tg rats; however, prior cocaine self...Continue Reading

References

Jan 1, 1992·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S K OhH Kornfeld
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·J M Arnold, D C Roberts
Apr 18, 1998·Brain Pathology·C A WileyC L Achim
Dec 29, 1998·European Journal of Pharmacology·M Graziella De MontisJ E Smith
Mar 20, 1999·The Journal of Nutrition·K D Setchell, A Cassidy
Dec 6, 2000·Journal of Psychopharmacology·A NathM Mattson
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W ReidJ Bryant
Jul 18, 2002·Psychonomic Bulletin & Review·Alicia Grunow, Allen Neuringer
Jul 21, 2004·Journal of Neuroscience Methods·Jason M Williams, Jeffery D Steketee
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Drake MorganDavid C S Roberts
Jun 9, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Robert H PaulTimothy P Flanigan
Aug 2, 2005·The American Journal of Psychiatry·Peter W Kalivas, Nora D Volkow
Jun 27, 2006·Journal of Neurovirology·Janelle M SilversRosemarie M Booze
Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Michael A ColeCharles H Hinkin
Sep 4, 2007·Neurotoxicology·Janelle M SilversRosemarie M Booze
Jun 17, 2008·Science & Practice Perspectives·Eric J Nestler
Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erik B OlesonEvgeny A Budygin
Jan 24, 2009·Current Opinion in Pharmacology·Kent C BerridgeJ Wayne Aldridge
Feb 21, 2009·Journal of Computational Neuroscience·Hartmut Schmidt, Jens Eilers
Nov 17, 2009·Journal of Neuroimmunology·Jinsong PengSulie L Chang
Feb 24, 2010·Journal of Neurovirology·Shuxian HuR Bryan Rock
Aug 28, 2010·Journal of Neurochemistry·Mark J FerrisRosemarie M Booze
Jan 12, 2011·Biochemical Pharmacology·J F Keeler, T W Robbins
Jul 1, 2011·Molecular Neurobiology·Vishnudutt PurohitDavid Shurtleff
Mar 7, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Benjamin B GelmanVicki M Soukup
Apr 17, 2012·Journal of Neuroimmunology·Walter RoyalJoseph L Bryant

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Citations

Feb 23, 2020·Journal of the Experimental Analysis of Behavior·Y Wendy HuynhJennifer E Murray
Jan 31, 2019·Scientific Reports·Kristen A McLaurinCharles F Mactutus
Dec 21, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kristen A McLaurinCharles F Mactutus
Jun 14, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica M IllenbergerRosemarie M Booze
Apr 2, 2021·Neuroscience Letters·Susmita SilShilpa Buch
Apr 11, 2021·Neuroscience Letters·Thomas J Cirino, Jay P McLaughlin
May 19, 2021·Journal of Neurovirology·Adam R DentonRosemarie M Booze
Jun 6, 2021·Scientific Reports·Kristen A McLaurinRosemarie M Booze

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Methods Mentioned

BETA
transgenic
Assay
scintillation spectrometry

Software Mentioned

BMDP
GraphPad Prism
Med
SPSS
PC

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