HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

FEBS Letters
T TasaraU Hübscher

Abstract

Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells.

References

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Citations

Oct 12, 2007·Biochemical and Biophysical Research Communications·Iris Oz GleenbergAmnon Hizi
Jan 20, 2009·The Journal of Biological Chemistry·Thomas A WilkinsonSamson A Chow
Jul 3, 2009·Journal of Virology·Sharon P Moore, David J Garfinkel
Nov 6, 2009·Journal of Virology·Lise RivièreAndrea Cimarelli
Aug 12, 2005·Cytogenetic and Genome Research·F-X WilhelmA Gabriel
Jul 16, 2013·Virology Journal·Guney BosoNikunj V Somia
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Aurélie MousnierCatherine Dargemont
Jun 30, 2012·The FEBS Journal·Michal MaesAssaf Friedler
Sep 13, 2013·Journal of Medicinal Chemistry·Roberto Di Santo
Nov 18, 2006·Virology·Aliza G LloydLubbertus C F Mulder
Aug 16, 2002·Antiviral Chemistry & Chemotherapy·Zeger DebyserMyriam Witvrouw
Aug 17, 2005·Journal of Biomolecular Screening·Sinu JohnColleen B Jonsson
Jul 1, 2016·Microbiology and Molecular Biology Reviews : MMBR·Guangdi Li, Erik De Clercq
Dec 29, 2012·FEBS Letters·Amit ChakrabortyBai-Lian Li
Jul 5, 2007·Journal of Medicinal Chemistry·Zhengqiang WangRobert Vince
Jul 1, 2010·Journal of Medicinal Chemistry·Shintaro SuzukiHirokazu Tamamura
Jan 30, 2007·Archives of Biochemistry and Biophysics·Iris Oz GleenbergAmnon Hizi

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