PMID: 9531014Apr 8, 1998Paper

HIV-1 strain-associated variability in infection of primary neuroglia

Journal of Neurovirology
M McCarthyC Wood

Abstract

Qualitative differences among strains of Human Immunodeficiency Virus type 1 (HIV-1) may influence viral infectivity for cells of the central nervous system (CNS) and determine or at least significantly influence the neuropathogenesis of brain infection. In this study, we compared infectivity for these cells in vitro among several different laboratory-adapted HIV-1 strains differing in cellular tropism. These strains included three lymphotropic strains (SF2, NL4-3, and SG3.1), two macrophage-tropic strains (SF128A, SF162), and one brain-derived strain (YU2). In microglia, macrophage-tropic strain SF128A established productive infection while the lymphotropic strain SF2 did not. In infected astrocytes, all HIV-1 strains transiently produced variable and much lower levels of p24 antigen. Viral DNA env or tat gene sequences were amplified from infected astrocytes; the amplified signals varied among HIV-1 strains, but the strongest viral DNA signals were obtained from cells infected by the lymphotropic strains SF2 and SG3.1. Transfection of astrocytes with infectious HIV-1 proviral DNA clones confirmed the observation that HIV-1 strains differ in their ability to replicate in astrocytes. Transfection revealed post-entry blocks to r...Continue Reading

Citations

Sep 22, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anjana Yadav, Ronald G Collman
Jun 8, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebeca GeffinMicheline McCarthy
May 12, 2005·Virus Research·Susanne Kramer-HämmerleRuth Brack-Werner
Oct 19, 2004·Clinical Microbiology Reviews·R Bryan RockPhillip K Peterson
May 23, 2006·Retrovirology·Mohammad GhafouriBassel E Sawaya
Dec 25, 2010·Journal of Pharmacy & Bioallied Sciences·Ashish Swarup VermaAnchal Singh
Nov 10, 2013·Immunologic Research·Rebeca Geffin, Micheline McCarthy
Sep 16, 2014·Neuroscience Research·Ashok ChauhanArwa Mujahid Abdullah
Dec 3, 2014·Microbial Pathogenesis·Ashok Chauhan, Mehrab Khandkar
Sep 23, 2014·Journal of Neurovirology·Sarah B JosephRonald Swanstrom
Aug 13, 2020·Journal of Neuropathology and Experimental Neurology·Michelle N SullivanJoseph L Mankowski
Mar 23, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rebeca GeffinMicheline McCarthy
Dec 23, 2017·Current HIV Research·Olivia D Council, Sarah B Joseph
Aug 30, 2018·Scientific Reports·Rahul Dev JayantMadhavan Nair

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