HIV-1 subtype D infections among Caucasians from Northwestern Poland--phylogenetic and clinical analysis.

PloS One
Miłosz ParczewskiAnna Boroń-Kaczmarska

Abstract

HIV-1 subtype D infections, which are associated with a faster rate of progression and lymphocyte CD4 decline, cognitive deficit and higher mortality, have rarely been found in native Europeans. In Northwestern Poland, however, infections with this subtype had been identified. This study aimed to analyze the sequence and clinical data for patients with subtype D using molecular phylogeography and identify transmission clusters and ancestry, as well as drug resistance, baseline HIV tropism and antiretroviral treatment efficacy. Phylogenetic analyses of local HIV-1 subtype D sequences were performed, with time to the most recent common ancestor inferred using bayesian modeling. Sequence and drug resistance data were linked with the clinical and epidemiological information. Subtype D was found in 24 non-immigrant Caucasian, heterosexually infected patients (75% of females, median age at diagnosis of 49.5 years; IQR: 29-56 years). Partial pol sequences clustered monophyletically with the clades of Ugandan origin and no evidence of transmission from other European countries was found. Time to the most common recent ancestor was 1989.24 (95% HPD: 1968.83-1994.46). Baseline drug resistance to nucleoside reverse transcriptase inhibitor...Continue Reading

References

Jan 1, 1993·AIDS Research and Human Retroviruses·I V Patrascu, O Dumitrescu
Apr 3, 2001·AIDS Research and Human Retroviruses·K L BarlowJ P Clewley
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M Thomson, R Nájera
May 23, 2002·AIDS Research and Human Retroviruses·Africa HolguínVincent Soriano
Aug 2, 2003·AIDS Research and Human Retroviruses·Aida EstevesWanda F Canas-Ferreira
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphane HuéOliver G Pybus
Dec 24, 2005·Current Opinion in Infectious Diseases·Anna Maria Geretti
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tommy F Liu, Robert W Shafer
May 11, 2006·PLoS Biology·Alexei J DrummondAndrew Rambaut
Feb 22, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pontiano KaleebuJames A G Whitworth
Mar 16, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A C PalmaUNKNOWN Portuguese SPREAD Network
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 24, 2007·The Journal of Infectious Diseases·Dimitrios ParaskevisUNKNOWN Multicentre Study on HIV Heterogeneity
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Dec 11, 2007·Nature Biotechnology·Thomas LengauerRolf Kaiser
Mar 21, 2008·PLoS Medicine·Fraser LewisAndrew J Leigh Brown
Aug 1, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew KayeChris Birch
Aug 19, 2008·Journal of Virological Methods·Kristel Van LaethemAnne-Mieke Vandamme
Oct 14, 2008·Infectious Agents and Cancer·Luigi BuonaguroFranco M Buonaguro
Nov 14, 2008·AIDS·Bluma G BrennerUNKNOWN Montreal PHI Cohort and HIV Prevention Study Groups
Jan 23, 2009·Journal of Virology·Stéphane HuéUNKNOWN UK Collaborative Group on HIV Drug Resistance
Mar 14, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria Teresa CuevasUNKNOWN Spanish Group of HIV-1 Antiretroviral Resistance Studies in the Basque Country
Apr 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna Maria GerettiUNKNOWN UK Collaborative Group on HIV Drug Resistance
Jul 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ned SacktorThomas C Quinn
Sep 26, 2009·PLoS Pathogens·Gareth J HughesUNKNOWN UK HIV Drug Resistance Collaboration
Oct 20, 2009·The Journal of Infectious Diseases·Jurgen VercauterenCharles A B Boucher
Oct 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephanie BousheriHuyen Cao
Dec 17, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Noah KiwanukaChristopher C Whalen
Mar 9, 2010·Journal of the International AIDS Society·Philippa J EasterbrookMark Zuckerman
Jun 1, 2010·Journal of Medical Virology·Grzegorz P StańczakAndrzej Horban

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Citations

Nov 28, 2013·AIDS Research and Human Retroviruses·Pavel B BaryshevNatalya M Gashnikova
Apr 22, 2014·Journal of the International AIDS Society·Miłosz ParczewskiMagdalena Leszczyszyn-Pynka
Feb 7, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Miłosz ParczewskiAnna Urbańska
Jul 28, 2015·AIDS Research and Human Retroviruses·Ann M DennisJoseph J Eron
Sep 25, 2014·The Journal of Antimicrobial Chemotherapy·Miłosz ParczewskiAnna Urbańska
Dec 27, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Miłosz ParczewskiAnna Urbańska
Jan 18, 2020·PLoS Computational Biology·Sayaka MiuraSudhir Kumar
Mar 25, 2020·Frontiers of Medicine·Xiaoxu HanHong Shang
Feb 5, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Miłosz ParczewskiAnna Urbańska
Aug 18, 2021·Scientific Reports·Karol SerwinMiłosz Parczewski

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Clustal
REGA
Viroseq
Simplot
geno2pheno
PAUP
PHYML
Statistica
MEGA
TreeAnnotator

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