HIV-1 superinfection and viral diversity

AIDS
Kimber L GrossRobert M Grant

Abstract

Sequential acquisition of viral variants, or HIV-1 superinfection, has been proposed to explain the high fractions of recombinant viruses observed in some geographical regions, but only a few cases of superinfection in humans have been reported. Animal models suggest that susceptibility to superinfection may be restricted to a short period of time after initial infection, possibly due to maturation of broad antiviral immune responses. A mathematical model involving a system of differential equations was developed to identify transmission and superinfection patterns that would lead to the observed global patterns of viral diversity. Requirements for a high prevalence of infections involving recombinant viruses include high viral infectivity, the presence of highly sexually active core groups, and introduction of divergent viruses early in the epidemic spread of HIV-1. Restricted superinfection could explain the persistent predominance of single virus subtypes in regions with well-established HIV-1 epidemics. The rate of recombination within individuals was not strongly related to recombinant fractions in populations. HIV-1 superinfection restricted to early HIV-1 infection could account for the high fraction of recombinant virus...Continue Reading

References

Dec 7, 1992·Journal of Theoretical Biology·M A Nowak, R M May
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W S Hu, H M Temin
Jul 1, 1987·The Journal of Infectious Diseases·R M GrantW Winkelstein
Nov 4, 1995·Lancet·A W ArtensteinF E McCutchan
Nov 4, 1995·Lancet·S K BrodineD S Burke
Mar 9, 1995·Nature·M T Nakamura
Mar 9, 1995·Nature·D L RobertsonB H Hahn
Nov 26, 1997·Journal of Virology·D P WooleyR C Desrosiers
Oct 28, 1998·The Journal of Clinical Investigation·M MoriuchiA S Fauci
Aug 24, 2000·AIDS Research and Human Retroviruses·G Becker-PergolaS H Eshleman
Jun 22, 2001·Nature·F LiljerosY Aberg
Aug 31, 2001·American Journal of Public Health·D BinsonJ A Catania
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason T BlackardKenneth H Mayer
Sep 6, 2002·The New England Journal of Medicine·Stephanie JostLuc Perrin
Sep 6, 2002·The New England Journal of Medicine·Philip J R Goulder, Bruce D Walker
Jul 19, 2003·The Journal of Infectious Diseases·Matthew J GonzalesRobert W Shafer

❮ Previous
Next ❯

Citations

Jun 4, 2013·The Lancet Infectious Diseases·Andrew D ReddAaron A R Tobian
Feb 4, 2012·AIDS Care·Carol Dawson RoseStephen Morin
Mar 3, 2007·AIDS Research and Human Retroviruses·Maarja AdojaanMart Ustav
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Omar BagasraJeremy S Lee
Dec 14, 2011·Current Opinion in Infectious Diseases·Laura Waters, Erasmus Smit
Sep 26, 2007·Retrovirology·Antoinette C van der Kuyl, Marion Cornelissen
Nov 26, 2013·The Journal of Infectious Diseases·Gabriel A WagnerDavey M Smith
May 3, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anita ShetMartin Markowitz
May 15, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maria XiridouKachit Choopanya
Oct 20, 2006·Expert Opinion on Biological Therapy·Omar Bagasra
Sep 27, 2016·Journal of Mathematical Analysis and Applications·Daozhou GaoShigui Ruan
Feb 6, 2015·PLoS Computational Biology·Bence FerdinandyViktor Müller
Sep 28, 2016·Mathematical Medicine and Biology : a Journal of the IMA·N J MalunguzaZ Mukandavire

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Ricardo Sobhie DiazMichael P Busch
Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Jesse E Taylor, Bette T Korber
Journal of Acquired Immune Deficiency Syndromes : JAIDS
Maria PernasCecilio Lopez-Galindez
© 2022 Meta ULC. All rights reserved