HIV-1 Superinfection Resembles Primary Infection

The Journal of Infectious Diseases
Daniel J ShewardCarolyn Williamson

Abstract

The relevance of superinfection as a model to identify correlates of protection against human immunodeficiency virus (HIV) depends on whether the superinfecting transmission resembles primary infection, which has not been established. Here, we characterize the genetic bottleneck in superinfected individuals for the first time. In all 3 cases, superinfection produced a spike in viral load and could be traced to a single, C-C chemokine receptor 5-tropic founder virus with shorter, less glycosylated variable regions than matched chronic viruses. These features are consistent with primary HIV transmission and provide support for the use of superinfection as a model to address correlates of protection against HIV.

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Citations

Mar 14, 2017·PloS One·Colleen R CourtneyRalf Dürr
Apr 7, 2018·PloS One·Laura HebberechtChris Verhofstede
Jun 16, 2017·Journal of Virology·Gabriel A WagnerDavey M Smith
Feb 26, 2016·AIDS Research and Human Retroviruses·Marion CornelissenAntoinette C van der Kuyl
Aug 28, 2020·Journal of the International Association of Providers of AIDS Care·Kevin D DieckhausAvina Sarna
Feb 11, 2020·Frontiers in Microbiology·Yu ZhangLin Li

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