HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference

Current HIV Research
Jay P McLaughlinJason J Paris

Abstract

Exposure to HIV-1 trans-activator of transcription (Tat) protein potentiates the psychostimulant effects of cocaine, but the functional consequences of the interaction between HIV-1 Tat and other abused drugs is poorly understood. We hypothesized that exposure to HIV-1 Tat would potentiate the rewarding effects of ethanol. GT-tg transgenic mice, where Tat protein is conditionally expressed in brain by a doxycycline-dependent GFAP-linked promoter, were used to test the effects of Tat on ethanol-conditioned place preference (CPP). Compared to uninduced littermates or doxycycline-treated C57BL/6J mice, Tat-induced GT-tg mice demonstrated a 3-fold increase in ethanol-CPP. The potentiation of ethanol-CPP was dependent on the dose and duration of doxycycline treatment used to express Tat protein. Moreover, induction of Tat protein after the extinction of CPP produced reinstatement without additional exposure to ethanol. Together, these data suggest that CNS exposure to HIV-1 Tat protein potentiates the rewarding effects of ethanol in mice.

Citations

May 13, 2017·Brain, Behavior, and Immunity·James P KesbySvetlana Semenova
Jan 3, 2018·PloS One·Amanda L PersonsT Celeste Napier
Dec 10, 2020·Alcoholism, Clinical and Experimental Research·Mark K BrittonRonald A Cohen
Apr 11, 2021·Neuroscience Letters·Thomas J Cirino, Jay P McLaughlin

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