HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study.

The Journal of Infectious Diseases
Geoffrey S GottliebJames I Mullins

Abstract

Understanding the characteristics of human immunodeficiency virus (HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome (AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity (0.2%-5.6% [median, 0.86%]), V1-V2 loop length (58-93 aa), and potential N-linked glycosylation sites (n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL.

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Citations

Nov 10, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cheol Kyu HwangHorace H Loh
Sep 25, 2010·The Journal of Infectious Diseases·Christian L BoutwellTodd M Allen
Nov 7, 2012·The Journal of Infectious Diseases·Oliver LaeyendeckerSusan H Eshleman
Jun 15, 2010·Current Opinion in HIV and AIDS·Brandon F Keele
Dec 17, 2009·AIDS·Deborah J AndersonKenneth H Mayer
Sep 24, 2010·Science Translational Medicine·Laura HeathJames I Mullins
Apr 9, 2010·Journal of Virology·Katharine J BarGeorge M Shaw
Feb 6, 2009·Journal of Virology·M-R AbrahamsUNKNOWN Center for HIV-AIDS Vaccine Immunology Consortium
Jun 10, 2009·Retrovirology·Benjamin N BimberHa Youn Lee
Sep 17, 2010·PloS One·Alicia ArnottUNKNOWN Pulse Study Team
Mar 15, 2011·PloS One·Mary S CampbellUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
May 21, 2010·PLoS Pathogens·Hui LiGeorge M Shaw
Oct 3, 2008·Mayo Clinic Proceedings·Jonathan Moss, Carl E Rosow
Mar 18, 2011·Reviews in Medical Virology·Kevin K AriënGuido Vanham
Apr 24, 2014·Therapeutic Advances in Vaccines·Yehuda Z Cohen, Raphael Dolin
Apr 7, 2010·Critical Reviews in Clinical Laboratory Sciences·Tommy Tsan-Yuk LamJulian W Tang
Sep 30, 2020·Annual Review of Virology·Bernadien M NijmeijerTeunis B H Geijtenbeek

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