HIV-1 Vif and APOBEC3G: multiple roads to one goal

Retrovirology
Joao Goncalves, Mariana Santa-Marta

Abstract

The viral infectivity factor, Vif, of human immunodeficiency virus type 1, HIV-1, has long been shown to promote viral replication in vivo and to serve a critical function for productive infection of non-permissive cells, like peripheral blood mononuclear cells (PBMC). Vif functions to counteract an anti-retroviral cellular factor in non-permissive cells named APOBEC3G. The current mechanism proposed for protection of the virus by HIV-1 Vif is to induce APOBEC3G degradation through a ubiquitination-dependent proteasomal pathway. However, a new study published in Retrovirology by Strebel and colleagues suggests that Vif-induced APOBEC3G destruction may not be required for Vif's virus-protective effect. Strebel and co-workers show that Vif and APOBEC3G can stably co-exist, and yet viruses produced under such conditions are fully infectious. This new result highlights the notion that depletion of APOBEC3G is not the sole protective mechanism of Vif and that additional mechanisms exerted by this protein can be envisioned which counteract APOBEC3G and enhance HIV infectivity.

References

Sep 1, 1992·Virology·L Fan, K Peden
Dec 10, 1998·Nature Medicine·J H SimonM H Malim
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Nov 9, 2000·Journal of Virology·A Ohagen, D Gabuzda
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·B StrackH G Gottlinger
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
May 17, 2003·Science·Denise LecossierAllan J Hance
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jul 16, 2003·Cell·Roberto MarianiNathaniel R Landau
Oct 7, 2003·Nature Medicine·Mariana MarinDavid Kabat
Oct 15, 2003·Trends in Molecular Medicine·Jean-Pierre VartanianSimon Wain-Hobson
Nov 15, 2003·Current Biology : CB·Silvestro G ConticelloMichael S Neuberger
Feb 18, 2004·The Journal of Biological Chemistry·Bastien MangeatDidier Trono
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bärbel SchröfelbauerNathaniel R Landau
Mar 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hal P BogerdBryan R Cullen
Mar 12, 2004·Biochemical and Biophysical Research Communications·Sylvie DussartEtienne Decroly
Mar 20, 2004·Science·Priscilla TurelliDidier Trono
Apr 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hongzhan XuVinay K Pathak
May 14, 2004·Journal of Virology·Yong-Hui ZhengB Matija Peterlin
May 25, 2004·Journal of Cellular Biochemistry·Jinliang LiDavid J Volsky
May 26, 2004·The Journal of Biological Chemistry·Shan CenLawrence Kleiman
Jun 24, 2004·Journal of Molecular Biology·Frederico Aires da SilvaJoao Goncalves
Jun 25, 2004·The Journal of Biological Chemistry·Timothy M Alce, Waldemar Popik
Jul 13, 2004·Current Opinion in Immunology·Francisco Navarro, Nathaniel R Landau
Aug 3, 2004·Science·Kate N BishopMichael H Malim

❮ Previous
Next ❯

Citations

Oct 25, 2014·Viruses·Pinar Iyidogan, Karen S Anderson
Dec 7, 2017·International Reviews of Immunology·Faezeh BorzooeeMani Larijani
Jan 30, 2020·Current HIV Research·Poramed Winichakoon, Siripong Tongjai
Sep 13, 2017·AIDS Research and Therapy·Michael Grant, Mani Larijani
Sep 27, 2018·Frontiers in Microbiology·Lin ChenChristian Schölz
Sep 16, 2021·Journal of Virology·Susana BandarraIsabel Barahona

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
ubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.