HIV-2 infection in 12 European residents: virus characteristics and disease progression

AIDS
Marchina E van der EndeA D Osterhaus

Abstract

To assess the disease progression rate among 12 HIV-2-infected West European residents (nine of West African descent), compared with the disease progression rate among HIV-1-infected individuals of the same population, and the characteristics of the HIV-2 strains involved. HIV-2-infected individuals were identified by commercially available serological assays, their clinical status and CD4+ cell counts were monitored, and HIV-2 was isolated from their peripheral blood mononuclear cells. T-cell-line tropism and syncytium-inducing capacities of the isolated viruses were determined and their phylogenetic relationships were analysed by comparing polymerase chain reaction-amplified nucleotide sequences of reverse transcriptase (RT) gene segments. Eight of the 12 HIV-2-infected individuals presented with progressive disease and one of them progressed from Centers for Disease Control and Prevention group A1 to A3 within 36 months after seroconversion. The ratios of asymptomatic versus symptomatic individuals among residents of the Rotterdam region of West African descent were 2:7 for HIV-2 and 8:9 for HIV-1-infected individuals. HIV-2 was isolated from six of the nine individuals with progressive disease. The time required for virus i...Continue Reading

Citations

Aug 2, 2000·Journal of Virological Methods·M SchuttenH G Niesters
Jul 31, 1998·Vaccine·E G HulskotteA D Osterhaus
Sep 2, 1998·Current Opinion in Immunology·H C WhittleS Rowland-Jones
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Jun 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hetty BlaakAlbert D M E Osterhaus
Nov 7, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M E van der EndeM Schutten

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