HIV and cytomegalovirus viral load and clinical outcomes in AIDS and cytomegalovirus retinitis patients: Monoclonal Antibody Cytomegalovirus Retinitis Trial

AIDS
Douglas A JabsStudies of Ocular Complications of AIDS Research Group

Abstract

To determine the association of cytomegalovirus (CMV) viremia with mortality and CMV retinitis progression in newly diagnosed and relapsed CMV retinitis. Ancillary study of a randomized, placebo-controlled, phase III clinical trial. A total of 83 patients with AIDS and CMV retinitis, enrolled during the first phase of the Monoclonal Antibody Cytomegalovirus Retinitis Trial, were administered MSL-109 or placebo as adjuvant therapy for CMV retinitis. Mortality and CMV retinitis progression. Treatment with MSL-109 did not predict either progression of CMV retinitis or mortality. Detection in plasma CMV DNA at baseline predicted mortality, but CMV antigenemia did not. CMV DNA was a better predictor of mortality than a high HIV viral load. Neither CMV DNA nor antigenemia predicted the progression of CMV retinitis. Among newly diagnosed patients, there was a decline in the proportion with detectable CMV viral load and CMV antigenemia in response to anti-CMV therapy. However, there was a rebound in CMV viral load to 25% and CMV antigenemia to 54.6% at 6 months. In relapsed patients, anti-CMV therapy was not associated with a change in the percentage with detectable CMV-DNA or CMV antigenemia over time. In patients with AIDS and CMV re...Continue Reading

References

Dec 23, 1993·The New England Journal of Medicine·D R HooverR A Kaslow
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·D PodzamczerF Gudiol
Aug 1, 1997·American Journal of Ophthalmology·D A Jabs, J G Bartlett
Feb 7, 1998·The Journal of Clinical Investigation·S A SpectorM J Stempien
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S WalmsleyT Mazzulli
Oct 26, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D TorrúsJ Sánchez-Payá
Nov 30, 1999·JAMA : the Journal of the American Medical Association·S M WhitcupM A Polis
Feb 3, 2000·Journal of Clinical Microbiology·P WattanamanoM A Beilke
May 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ChevretJ M Molina
Jul 24, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M BoeckhJ A Zaia

❮ Previous
Next ❯

Citations

Aug 18, 2012·Virologica Sinica·Jun JinChunlai Jiang
Feb 1, 2003·Controlled Clinical Trials·Adele M Kaplan GilpinUNKNOWN Studies of Ocular Complications of AIDS Research Group
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John H KempenJames Tonascia
Nov 30, 2006·DNA and Cell Biology·Kamla Dutt, Ifeoma Ezeonu
Jul 28, 2011·The Journal of Infectious Diseases·Thomas C Quinn
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ashley E FoutsBecket Feierbach
May 6, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Christoph SteiningerTheresia Popow-Kraupp
Jan 16, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daisuke MizushimaHiroyuki Gatanaga
Dec 14, 2018·International Journal of Molecular Sciences·Michael M McVoyLawrence M Kauvar
Jul 30, 2004·The Journal of Antimicrobial Chemotherapy·Kathryn L Springer, Adriana Weinberg
Feb 1, 2014·Microbiology Spectrum·Edith A SeedahJennifer A Maynard
Aug 28, 2021·International Journal of Molecular Sciences·Evi B StrubleDorothy Scott

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.