HIV and hepatitis C virus co-infection

The Lancet Infectious Diseases
Jürgen K Rockstroh, U Spengler

Abstract

Since the decline in HIV-related morbidity and mortality after introduction of highly active antiretroviral therapy (HAART) in 1996, liver disease caused by chronic infection with hepatitis C virus (HCV) has become an increasingly important cause of morbidity and mortality among HIV-infected patients infected parenterally with HCV in more developed countries. A third of HIV-infected individuals in Europe and the USA have HCV co-infection. HIV accelerates HCV liver disease especially when HIV-associated immunodeficiency progresses. With the introduction of pegylated interferon in combination with ribavirin, greatly improved treatment options for patients with HIV and HCV co-infection have become available and have led to sustained virological response rates of up to 40%. Furthermore, recent cohort analyses have shown that immune reconstitution induced by HAART can improve the course of hepatitis C leading to a decline in liver-related mortality. However, patients with HCV co-infection are at increased risk of hepatotoxicity from HAART. Owing to the high rates of HIV and HCV co-infection worldwide, new improved treatment strategies and guidelines for the management of co-infection remain a major future goal.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A KarpasF Hill
Nov 1, 1995·British Journal of Haematology·G TagarielloA Alberti
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J Alter
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H ZylberbergS Pol
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouUNKNOWN MultivirC Group
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S SauledaJ Guardia
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriel PerlemuterChristian Bréchot
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Mark S SulkowskiDavid L Thomas
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashok Kumar B JainJohn J Fung
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dinesh KumarJacob George
Jun 12, 2003·Seminars in Liver Disease·Valentina MontessoriJulio S G Montaner

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Citations

Feb 22, 2012·AIDS and Behavior·Douglas BruceUNKNOWN Adolescent Medicine Trials Network for HIV/AIDS Interventions
Jun 19, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Debasish Basu
Aug 20, 2011·Irish Journal of Medical Science·A A DillonC Bergin
Sep 20, 2012·Current Neurology and Neuroscience Reports·Micheline McCarthy, Melissa R Ortega
Mar 5, 2003·Journal of Psychosomatic Research·H Michael Dreher
Apr 25, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jyh-You LiuJiun-Nong Lin
Apr 13, 2007·AIDS Patient Care and STDs·Jaydeep S Kadam, Andrew H Talal
May 21, 2013·AIDS Patient Care and STDs·Sylvie JonckheereJean Cyr Yombi
Jul 21, 2011·The Pediatric Infectious Disease Journal·Gemma Claret-TeruelClàudia Fortuny
Feb 19, 2011·AIDS·María López-DiéguezUNKNOWN GESIDA 37/03-FIPSE 36465/03-NEAT IG5 Study Group
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Everton HadlichLuciano Zubaran Goldani
Jul 21, 2010·Harm Reduction Journal·Heino Stöver, Ingo Ilja Michels
Jul 20, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Paula BraitsteinRobert S Hogg
Mar 1, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tom Wong, Samuel S Lee
Jun 8, 2007·Emerging Infectious Diseases·Christian LaurentEric Delaporte
Oct 30, 2012·Future Virology·Eric G MeissnerShyamasundaran Kottilil
Sep 1, 2006·Expert Review of Clinical Immunology·Hendrik Streeck, Jürgen K Rockstroh
Sep 18, 2013·Gastroenterology·Markus Grompe, Stephen Strom
Jan 5, 2010·Journal of Virological Methods·Elisa De CrignisDavide Gibellini
Jun 19, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Arianna LoregianGiorgio Palù
Aug 2, 2006·Gastroenterology Clinics of North America·Homayon Sidiq, Victor Ankoma-Sey
May 16, 2007·Journal of Viral Hepatitis·M S Sulkowski, Y Benhamou
Apr 17, 2007·Annals of the New York Academy of Sciences·Paul L A M CorstjensHans J Tanke
Jan 9, 2009·Journal of the American Academy of Nurse Practitioners·Renee Pozza

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