HIV and SIV Associated Thrombocytopenia: An Expanding Role for Platelets in the Pathogenesis of HIV.

Drug Discovery Today. Disease Mechanisms
Kelly A Metcalf Pate, Joseph L Mankowski

Abstract

Thrombocytopenia is common in HIV and SIV infection, and is often associated with disease progression. HIV and SIV-associated thrombocytopenia arise through multiple mechanisms, including decreased platelet production, increased platelet destruction due to HIV-mimetic anti-platelet antibodies, and increased use of activated platelets. Activated platelets have the potential to contribute to the pathogenesis of HIV and SIV by interacting directly with inflammatory cells and endothelium and by releasing soluble immunomodulatory cytokines.

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Citations

Dec 3, 2013·Journal of Neuroinflammation·Donna C DavidsonSanjay B Maggirwar
Nov 14, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kelly A Metcalf PateJoseph L Mankowski
Feb 6, 2020·Journal of Thrombosis and Haemostasis : JTH·Joseph W JacksonLeonard M Neckers
May 20, 2020·Clinical Practice and Cases in Emergency Medicine·Artur SchanderMichael B Carney
Mar 30, 2021·Frontiers in Immunology·Morris MadzimeHelen C Steel

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