HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

Immunity
Ann Chahroudi, Guido Silvestri

Abstract

T follicular helper (Tfh) cells provide crucial support to antigen-specific B cells. In this issue of Immunity, Schultz et al. (2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.

Citations

Mar 8, 2016·Trends in Microbiology·Brodie Miles, Elizabeth Connick
Jun 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer M DanShane Crotty
Jun 24, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colin Havenar-DaughtonShane Crotty

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