HIV and Vertebral Fractures: a Systematic Review and Metanalysis

Scientific Reports
Thales A S H IlhaMelissa O Premaor

Abstract

The survival of HIV-infected patients has increased with the advent of antiretroviral therapy with the emergence of new comorbidities. Vertebral fracture is a manifestation of reduced bone strength and osteoporosis. This study aims to assess the frequency of spine fractures in HIV-positive men and women aged over 18 years. We performed a systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies. Studies that evaluated morphometric and/or clinical vertebral fracture were included. In total 488 studies were found, of which 53 had their full texts evaluated. A total of 85,411 HIV positive individuals were identified in 26 studies. The meta-analysis of the prevalence of vertebral fractures included 12 studies with 10,593 subjects. The prevalence was 11.1% [95% confidence interval (95% CI) 4.5%, 25.0%, I2 98.2% p < 0.00001]. When we evaluated independently studies of clinical vertebral fracture and morphometric vertebral fracture, the prevalence was 3.9% (95% CI 0.9, 15.8, I2 96.4% p < 0.00001) and 20.2% (95% CI 15.7%, 25.6%, I2 69.9% p = 0.003) respectively. HIV-infected individuals had an odds ratio of vertebral fractures of 2.3 (95% CI 1.37, 3.85, I2 98.2% p < 0.00001) wh...Continue Reading

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Citations

Feb 9, 2019·Expert Review of Endocrinology & Metabolism·Luciano ColangeloSalvatore Minisola
Jun 1, 2019·PloS One·Juliana E BrondaniMelissa O Premaor
Apr 18, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristine M ErlandsonTodd T Brown
Jul 20, 2020·Calcified Tissue International·Luciana L de AlmeidaMelissa O Premaor
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Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat

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Methods Mentioned

BETA
X-ray

Software Mentioned

Cochrane Collaboration
PRISMA
LOGIT
RStudio RStudio Team
R

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