HIV, Antiretroviral Therapy, and Hypertensive Disorders in Pregnancy: A Systematic Review and Meta-analysis

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Joyce L BrowneKerstin Klipstein-Grobusch

Abstract

There are data to suggest that infection with HIV or use of highly active antiretroviral therapy increases the risk of hypertensive disorders in pregnancy. This systematic review and meta-analysis aims to provide an overview of the research hitherto. A systematic review of EMBASE, PubMed, and The Cochrane Library databases was conducted to obtain articles about the association between HIV in pregnancy and/or HIV therapy and the risk of developing pregnancy-induced hypertension (PIH), pre-eclampsia, eclampsia, or Hemolysis Elevated Liver enzymes Low Platelet count syndrome. Quality of articles was evaluated with an adapted Cochrane Collaboration bias assessment tool. Relative risks (RRs) were pooled with a random-effects meta-analysis weighted by the inverse of their variance. Of the 2136 articles screened, 28 studies were eligible for inclusion; 15 studies reported on the association with PIH, 16 on pre-eclampsia, 5 on eclampsia, and 3 articles on HIV therapy regimens. All articles had a high risk of bias, and between-study heterogeneity was considerable. Based on the meta-analysis, there does not seem to be an association between HIV and PIH [RR 1.26, 95% confidence interval (CI): 0.87 to 1.83, I = 78.6%], pre-eclampsia (RR 1....Continue Reading

References

Jun 5, 1993·Lancet·J M Roberts, C W Redman
Sep 24, 1998·British Journal of Obstetrics and Gynaecology·P Brocklehurst, R French
May 11, 2000·Infectious Diseases in Obstetrics and Gynecology·P J GoldsteinJ L Sever
Feb 28, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B ChanrachakulP Panburana
Nov 28, 2001·The American Journal of Clinical Nutrition·M L DreyfussW W Fawzi
Aug 5, 2004·Obstetrics and Gynecology·K A FrankR C Schackis
Nov 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rosiane MattarSilvia Daher
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
May 11, 2006·Journal of Clinical Nursing·Candice BodkinGayle Langley
Oct 3, 2006·Lancet·Carine RonsmansUNKNOWN Lancet Maternal Survival Series steering group
Jan 25, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xinwen WangChangyi Chen
Apr 28, 2007·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H E OnahT C Oguanuo
May 22, 2007·Lancet·Lisa M AskieUNKNOWN PARIS Collaborative Group
Jun 6, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Erik R Kline, Roy L Sutliff
Jul 17, 2008·Tropical Doctor·Jessie LionelKenneth Mayer
Jul 25, 2009·Archives of Gynecology and Obstetrics·Biodun N OlagbujiVictor O Oboro
Sep 1, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Said AboudWafaie W Fawzi
Jun 18, 2010·The New England Journal of Medicine·R L ShapiroM Essex
Jul 6, 2010·Lancet·Eric A P SteegersRobert Pijnenborg
Oct 22, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cynthia FirnhaberThomas B Campbell
Apr 15, 2011·Immunological Reviews·Alba Munoz-SuanoAlexander G Betz
Jul 20, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Natasha ParekhRoger L Shapiro
Jul 6, 2012·The American Journal of Tropical Medicine and Hygiene·Ella T NkhomaSteven R Meshnick
Apr 25, 2013·Cardiovascular Journal of Africa·V M S KalumbaT D Naidoo
Jul 28, 2013·South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde·N C NgeneS van der Linde
Nov 13, 2013·Cardiovascular Journal of Africa·Nalini GovenderJagidesa Moodley
Aug 12, 2014·The Lancet Global Health·Lale SayLeontine Alkema
Jan 1, 2014·Pregnancy Hypertension·David HallDebbie Grové

❮ Previous
Next ❯

Citations

Dec 26, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hannah M Sebitloane, Dhayendre Moodley
Feb 19, 2017·Tropical Medicine & International Health : TM & IH·Emma KalkColleen A Wright
Jan 19, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hannah M SebitloaneBenn Sartorius
Oct 14, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicole Salazar-AustinUNKNOWN TSHEPISO Study Team
May 10, 2016·Obstetrics and Gynecology·Matilde SansonePasquale Martinelli
Nov 28, 2017·Journal of the International AIDS Society·Coceka N MnyaniJames A McIntyre
Sep 30, 2018·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R TownsendUNKNOWN IPPIC Network
Jun 4, 2020·Paediatric and Perinatal Epidemiology·Angela M BengtsonLandon Myer
Oct 3, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wendy N PhoswaJagidesa Moodley
Jul 26, 2019·Current Hypertension Reports·Sayuri PadayacheeThajasvarie Naicker
Feb 9, 2020·Progress in Cardiovascular Diseases·Samson OkelloMark J Siedner
Oct 16, 2021·AIDS and Behavior·Lissa N MandellDeborah L Jones
May 15, 2021·The Journal of Infectious Diseases·Cassandra Bruce-BrandPawel T Schubert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.