HIV antiviral drug resistance: patient comprehension

AIDS Care
C Sarai RaceyR S Hogg

Abstract

A patient's understanding and use of healthcare information can affect their decisions regarding treatment. Better patient understanding about HIV resistance may improve adherence to therapy, decrease population viral load and extend the use of first-line HIV therapies. We examined knowledge of developing HIV resistance and explored treatment outcomes in a cohort of HIV+ persons on highly active antiretroviral therapy (HAART). The longitudinal investigations into supportive and ancillary health services (LISA) cohort is a prospective study of HIV+ persons on HAART. A comprehensive interviewer-administrated survey collected socio-demographic variables. Drug resistance knowledge was determined using a three-part definition. Clinical markers were collected through linkage with the Drug Treatment Program (DTP) at the British Columbia Centre for Excellence in HIV/AIDS. Categorical variables were compared using Fisher's Exact Test and continuous variables using the Wilcoxon rank-sum test. Proportional odds logistic regression was performed for the adjusted multivariable analysis. Of 457 LISA participants, less than 4% completely defined HIV resistance and 20% reported that they had not discussed resistance with their physician. Overa...Continue Reading

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Citations

Mar 31, 2012·International Journal of Epidemiology·Katrina C DuncanRobert S Hogg
May 10, 2011·Journal of Health Psychology·Vienna R NightingaleNathan B Hansen
Jan 1, 2014·African Journal of Primary Health Care & Family Medicine·Lauren M Terblanche, Ethelwynn L Stellenberg
Oct 2, 2012·Journal of the American Pharmacists Association : JAPhA·Jennifer M CocohobaB Joseph Guglielmo
Mar 1, 2012·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Jean B NachegaRenslow Sherer
Jul 12, 2017·Schizophrenia Research and Treatment·Ciara Ní DhubhlaingLaura J Sahm

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