HIV-associated nephropathy: a diagnosis in evolution.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Patricio E Ray

Abstract

HIV-1 associated nephropathy (HIVAN) is a clinical and renal histological disease characterized by the presence of heavy proteinuria associated with focal segmental glomerulosclerosis and microcystic tubular dilatation. These renal lesions lead to renal enlargement and rapid progression to kidney failure. People from African ancestry show a unique susceptibility to develop HIVAN. The study by Wearne and colleagues, which includes the largest group of patients of African ancestry with HIVAN studied so far, describes a novel renal histological variant of HIVAN, and suggests that antiretroviral therapies improve the clinical outcome of all HIV-associated renal diseases. These findings, when interpreted in the context of recent advances in our understanding of the molecular pathogenesis and genetics of HIVAN, will facilitate the recognition of all clinical variants of HIVAN as well the planning of better screening, prevention, and treatment programs for all HIV nephropathies.

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Citations

Jun 24, 2014·Annales de cardiologie et d'angéiologie·J-M Halimi
Mar 13, 2015·Proteomics. Clinical Applications·Sofia PerazzoPatricio E Ray
Mar 24, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D R da SilvaF V Veronese
Dec 12, 2017·Expert Opinion on Pharmacotherapy·Steven MenezMohamed G Atta
Sep 2, 2017·The Journal of Pharmacology and Experimental Therapeutics·Rachel A Murphy, Monica A Valentovic
Feb 6, 2017·BMC Infectious Diseases·Lilishia GounderMahomed-Yunus S Moosa
Nov 24, 2016·BMC Nephrology·Nicola GlaserFlorian Neuhann
May 21, 2018·Experimental and Molecular Pathology·Fahad MubarizTapas K Makar

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