HIV-associated neurocognitive disorders (HAND) in a South Asian population - contextual application of the 2007 criteria.

BMJ Open
Lai Gwen ChanArlene Chua

Abstract

To estimate the prevalence of HIV-associated neurocognitive disorders (HAND) among HIV patients in a multiethnic South Asian population, describe the pattern of neurocognitive impairment in HAND and the factors associated with HAND. A cross-sectional survey of HIV-positive outpatients and inpatients. The sole referral centre for HIV/AIDS treatment in Singapore. Inclusion criteria were HIV positive, age between 21 and 80 years old and at least 3 years of education. Exclusion criteria included concomitant delirium, serious systemic disease or major psychiatric illness. 265 patients did not meet criteria or declined to participate. The final sample size was 132. The primary outcome measure was cognitive impairment based on performance on the Montreal Cognitive Assessment, International HIV Dementia Scale and Instrumental Activities of Daily Living. The secondary outcome measure was the classification of impairment based on the 2007 updated research nosology for HAND. The prevalence of HAND was 22.7% of which 70% (15.9% of total) were asymptomatic neurocognitive impairment, 23.3% (5.3% of total) were mild neurocognitive disorder and 6.7% (1.5% of total) were HIV-associated dementia. Increasing age (OR 1.104, 95% CI 1.054 to 1.155, ...Continue Reading

Citations

Mar 14, 2013·Journal of Neurovirology·Thep ChalermchaiUNKNOWN SEARCH 007 and 011 study groups
Dec 5, 2015·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Noshin KoenigChristopher Power
Aug 22, 2015·BioMed Research International·Taofiki A SunmonuBenedicta Y Oladimeji
Mar 10, 2015·Journal of Neurovirology·Mamata MishraUdaykumar Ranga
Oct 22, 2014·Journal of the International Association of Providers of AIDS Care·Abdulkareem Jika YusufOlusegun Baiyewu
Aug 28, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Flávio Trentin Troncoso, Lucieni de Oliveira Conterno
Mar 19, 2019·AIDS Research and Human Retroviruses·Irene PortillaJoaquín Portilla
Feb 15, 2019·BMC Infectious Diseases·Fiona C C ChanGermaine H F Chan
May 3, 2014·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Hiroshi MoriokaAtsushi Ajisawa
Dec 14, 2018·Scientific Reports·Georgette D KanmogneRobert K Heaton
Apr 24, 2021·HIV/AIDS : Research and Palliative Care·Abate Dargie WubetuBirhan Gebresillassie Gebregiorgis
Nov 25, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Karen Cilliers, Christo J F Muller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.