HIV broadly neutralizing antibody targets

Current Opinion in HIV and AIDS
Constantinos Kurt WibmerLynn Morris

Abstract

To provide an update on neutralizing antibody targets in the context of the recent HIV-1 envelope trimer structure, describe new antibody isolation technologies, and discuss the implications of these data for HIV-1 prevention and therapy. Recent advances in B-cell technologies have dramatically expanded the number of antibodies isolated from HIV-infected donors with broadly neutralizing plasma activity. These, together with the first high-resolution crystal and cryo-electron microscopy (cryo-EM) structures of a cleaved, prefusion HIV-1 trimer, have defined new regions susceptible to neutralization. This year, three epitopes in the gp120-gp41 interface were structurally characterized, highlighting the importance of prefusion gp41 as a target. Similar to many other broadly neutralizing antibody epitopes, these new antibodies define a target that is also highly glycan dependent. Collectively, the epitopes for broadly neutralizing antibodies now reveal a continuum of vulnerability spanning the length of the HIV-1 envelope trimer. Progress in the last year has provided support for the use of rationally stabilized whole HIV-1 trimers as immunogens for eliciting antibodies to multiple epitopes. Furthermore, the increasing number of br...Continue Reading

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Citations

Jun 28, 2016·Cell·Cassandra A SimonichJulie Overbaugh
Aug 26, 2016·Current Opinion in HIV and AIDS·Penny L Moore, Carolyn Williamson
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Methods Mentioned

BETA
phage display
PCR
glycosylation

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