HIV cure: global overview of bNAbs' patents and related scientific publications

Expert Opinion on Therapeutic Patents
Cristina PossasAkira Homma

Abstract

This article provides a global overview of patent deposits for broadly neutralizing antibodies (bNAbs), which have emerged as a key strategy for HIV cure and future HIV vaccines. Scientific and technological barriers to the discovery of an effective HIV vaccine in the last 40 years have raised concerns on the potential for relevant advances in this area. Nevertheless, recent breakthrough studies have identified novel immune pathways for new innovative HIV vaccine and HIV cure strategies. In our patent study, we have identified in a global scale, in the last decade, a sharp increase in the number of bNAbs' patent deposits related to HIV prevention and treatment strategies, reaching 90 bNAbs in 2017, protected by 184 different patent deposits. Refining our patent search to the different stages of bNAbs' development has also allowed us to identify 12 of them already at clinical stage of research (VRC01, 10E8, 3BNC117, 10-1074, 2G12, 2F5, KD-247, 4E10, PG9, PGDM1400, PGT121, and VRC07). We describe these recent breakthroughs and discuss the prospects and limitations of these novel strategies. Our results indicate the intellectual property outcomes of a scientific revolution in this field, expressing innovative modifications in anti...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D R BurtonR A Lerner
Dec 1, 1994·AIDS Research and Human Retroviruses·M PurtscherA Jungbauer
Feb 28, 2009·Nature Protocols·Kenneth SmithPatrick C Wilson
Mar 3, 2010·Annual Review of Immunology·John R Mascola, David C Montefiori
Aug 19, 2011·Nature·Laura M WalkerPascal Poignard
Jun 10, 2015·Nature Biotechnology·Cristina PossasAkira Homma
Dec 25, 2015·Science Translational Medicine·Rebecca M LynchUNKNOWN VRC 601 Study Team
Feb 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Colin Havenar-DaughtonShane Crotty
Jan 31, 2017·Immunological Reviews·Colin Havenar-DaughtonShane Crotty
Jan 31, 2017·Immunological Reviews·Laura E McCoy, Dennis R Burton
Feb 16, 2017·Molecular Therapy. Methods & Clinical Development·Sebastian P Fuchs, Ronald C Desrosiers
Aug 8, 2017·Science Immunology·LaTonya D WilliamsBarton F Haynes

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