HIV Dementia with a Decreased Cardiac 123 I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies

Internal Medicine
Masanori KuriharaShoji Tsuji

Abstract

Cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient' s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV. This case further emphasizes the importance of excluding other causes of autonomic neuropathy, including HIV infection, before interpreting MIBG scans.

References

Jul 21, 2004·Parkinsonism & Related Disorders·Winona TseWilliam Koller
Sep 17, 2013·AIDS Patient Care and STDs·Jessica Robinson-Papp, Sandeep K Sharma

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Citations

Mar 14, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed AljizeeriMouaz H Al-Mallah
Jun 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Vincenzo DonadioRocco Liguori

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