HIV-derived vectors for therapy and vaccination against HIV

Vaccine
F Di NunzioA-S Beignon

Abstract

Despite being at the origin of one of the world's most devastating public health concerns, the Human Immunodeficiency Virus (HIV) has properties that can be harnessed for therapeutic purposes. Indeed, the ability of HIV to efficiently deliver its genome into the nuclear compartment makes it an ideal vector for gene delivery into target cells. The design of so-called HIV-derived vectors, or more generally lentiviral vectors (LVs), consists in keeping only the parts of the virus that ensure efficient nuclear delivery while entirely removing all coding sequences that contribute towards the replication and pathogenesis of the virus: as a result, the vector genome is composed of less than 10% of the original virus genome and exclusively cis-active sequences. Proteins required for the formation of the lentivector particles and for the early steps of viral replication (including Gag- and Pol-derived proteins) are provided in trans. HIV-derived vectors are thus non-replicative virus shells that deliver genes of interest into target cells with high efficiency. Undoubtedly, there is a hopeful twist of fate in our fight against AIDS, which consists in using these vectors to achieve gene therapy and vaccination against HIV itself. This rev...Continue Reading

References

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Citations

Aug 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thipparat SuwanmaneeTal Kafri
Mar 29, 2014·Expert Reviews in Molecular Medicine·Mukerrem Hale TasyurekSalih Sanlioglu
Aug 9, 2013·Biotechnology Progress·João Vitor Dutra MolinoMaria Silvia Viccari Gatti
Sep 16, 2016·Frontiers in Immunology·Thomas D Norton, Elizabeth A Miller
Feb 8, 2018·Human Gene Therapy·Hale M TasyurekSalih Sanlioglu
Oct 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Douglas C MacdonaldWilliam C Rosenberg
Oct 6, 2015·PLoS Neglected Tropical Diseases·Mélissanne de WispelaerePhilippe Desprès

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