HIV DNA Vaccine: Stepwise Improvements Make a Difference

Vaccines
Barbara K FelberGeorge N Pavlakis

Abstract

Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.

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Citations

Jul 1, 2015·Human Vaccines & Immunotherapeutics·Jinyao LiGeorge N Pavlakis
Jul 1, 2015·Human Vaccines & Immunotherapeutics·Antonio ValentinBarbara K Felber
May 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenzhang ChaJinbo Li
Jul 6, 2017·Human Vaccines & Immunotherapeutics·Xintao HuBarbara K Felber
Oct 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xintao HuBarbara K Felber
Aug 28, 2019·Current Immunology Reviews·Pamela A Kozlowski, Anna Aldovini
Dec 4, 2019·Expert Review of Vaccines·Iván Del Moral-Sánchez, Kwinten Sliepen
Jun 19, 2019·Current HIV Research·Mona Sadat LarijaniSeyed Mehdi Sadat
Aug 31, 2020·Actualités pharmaceutiques·Élodie MatusikNicolas Picard
May 28, 2021·Frontiers in Oncology·Stephen C FredericoMasaki Terabe

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