HIV enhances substance P expression in human immune cells

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Wen Zhe HoSteven D Douglas

Abstract

Substance P (SP), a potent modulator of neuroimmunoregulation, is expressed in human immune cells. We observed elevated plasma SP levels in HIV-infected men compared with uninfected subjects. In the present study, we investigated the possible cellular source of the increased SP level caused by HIV infection. Using real-time reverse transcriptase-polymerase chain reaction, we demonstrated that monocyte-derived macrophages (MDM) and lymphocytes from both placental cord blood and adult peripheral blood expressed SP mRNA, which was significantly increased by HIV infection. HIV-induced SP expression was positively related to virus replication in the infected MDM. Purified recombinant HIV envelope glycoprotein 120 (gp120) derived from both the macrophage-tropic strain (MN) and the T lymphocyte-tropic strain (IIIB), when added to MDM cultures, enhanced SP mRNA expression. The gp120-induced SP expression was abrogated by pretreating the cells with soluble CD4. Furthermore, the activation of HIV in the latently infected promonocytic cell line (U1) and T-cell line (ACH-2) up-regulated SP mRNA expression. These data support the hypothesis that interaction of HIV and SP may have significant in vivo relevance to the immunopathogenesis of HI...Continue Reading

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Citations

Jul 26, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xu WangWen-Zhe Ho
Mar 31, 2004·Brain, Behavior, and Immunity·Kathy L KopniskyDianne M Rausch
Jan 20, 2004·Life Sciences·Jocelyn N PennefatherCarlo Alberto Maggi
Jul 6, 2002·Journal of Neuroimmunology·Jian-Ping LaiSteven D Douglas
Oct 16, 2010·Psychosomatic Medicine·Tami BentonDwight L Evans
Nov 30, 2002·Journal of Neuroimmunology·Chang Jiang GuoWen Zhe Ho
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Clarisa M BucknerJoan W Berman
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jeffrey S Barrett
Jul 25, 2013·Cell and Tissue Research·Erzsébet FehérGabriella Lengyel
Nov 26, 2011·Journal of Neuroimmunology·Mohammad M KhanTami D Benton
May 12, 2009·Trends in Immunology·Florin TulucSteven D Douglas
Mar 10, 2007·Brain, Behavior, and Immunity·Kathy L KopniskyYu Woody Lin
Dec 17, 2008·Annals of the New York Academy of Sciences·Steven D DouglasLaurie E Kilpatrick
Nov 26, 2010·Annals of the New York Academy of Sciences·Steven D Douglas, Susan E Leeman
Dec 8, 2004·Journal of Neuroimmunology·Wen-Zhe Ho, Steven D Douglas
Aug 23, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susmit Suvas
Mar 11, 2008·AIDS Research and Human Retroviruses·Steven D DouglasDwight L Evans
Apr 9, 2005·Clinical and Diagnostic Laboratory Immunology·Jian-Ping LaiWen-Zhe Ho
Mar 29, 2005·Experimental Biology and Medicine·Angel V DelgadoJames P Chambers
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandra SvenssonKristina Eriksson
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sherine F ElsawaKenneth L Bost
May 27, 2003·CNS Spectrums·Wen-Zhe HoSteven D Douglas

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