HIV entry inhibitors and their potential in HIV therapy.

Medicinal Research Reviews
Keduo QianKuo-Hsiung Lee

Abstract

This review discusses recent progress in the development of anti-HIV agents targeting the viral entry process. The three main classes (attachment inhibitors, co-receptor binding inhibitors, and fusion inhibitors) are further broken down by specific mechanism of action and structure. Many of these inhibitors are in advanced clinical trials, including the HIV maturation inhibitor bevirimat, from the authors' laboratories. In addition, the CCR5 inhibitor maraviroc has recently been FDA-approved. Possible roles for these agents in anti-HIV therapy, including treatment of virus resistant to current drugs, are also discussed.

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Dec 31, 2011·Biotechnology Letters·Roger A NassarAlexander M Klibanov
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Sep 18, 2012·Journal of Medicinal Chemistry·Keduo QianKuo-Hsiung Lee
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Feb 1, 2019·European Journal of Medicinal Chemistry·Haifeng WuKuo-Hsiung Lee

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