HIV incidence in US first-time blood donors and transfusion risk with a 12-month deferral for men who have sex with men.

Blood
Eduard GrebeBrian Custer

Abstract

In 2015, the US Food and Drug Administration published revised guidance that recommended a change in blood donor deferral of men who have sex with men (MSM) from an indefinite to a 12-month deferral since the donor last had sex with a man. We assessed whether HIV incidence in first-time blood donors or associated transfusion risk increased. Donations in 4 major blood collection organizations were monitored for 15 months before and 2 years after implementation of the 12-month MSM deferral policy. HIV-positive donations were classified as recently acquired or long-term using a recent infection testing algorithm and incidence in both periods estimated. Residual transfusion transmission risk was estimated by multiplying incidence by the length of the infectious window period. The latter was estimated using a model based on infectious dose and the sensitivity of nucleic acid testing. Factors associated with incident infection in each period were assessed using Poisson regression. Overall HIV incidence in first-time donors before implementation of the 12-month MSM deferral was estimated at 2.62 cases per 100 000 person-years (105 PY) (95% credible interval [CI], 1.53-3.93 cases/105 PY), and after implementation at 2.85 cases/105 PY (...Continue Reading

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Aug 3, 2020·Eduard Grebe

References

Aug 20, 2004·The New England Journal of Medicine·Susan L StramerUNKNOWN National Heart, Lung, and Blood Institute Nucleic Acid Test Study Group
May 26, 2012·Epidemiology·Reshma KassanjeeAlex Welte
Aug 4, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Beattie Rh Sturrock, Stuart Mucklow
Nov 30, 2019·Vox Sanguinis·Sheila F O'BrienUNKNOWN Surveillance, Risk Assessment and Policy Sub-group of the ISBT Transfusion Transmitted Diseases Working Party
Feb 23, 2020·Transfusion·Jefferson M JonesSridhar V Basavaraju

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Citations

Aug 30, 2020·Transfusion·Claire QuinerUNKNOWN Transfusion-Transmissible Infections Monitoring System (TTIMS)
Jan 19, 2021·Transfusion·Whitney R SteeleUNKNOWN Transfusion-Transmissible Infections Monitoring System (TTIMS)

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