HIV induces activation of phosphatidylinositol 4-kinase and mitogen-activated protein kinase by interacting with T cell CD4 surface molecules

European Journal of Immunology
H Schmid-AntomarchiB Rossi

Abstract

T cell surface CD4 molecules act as co-receptors that amplify the T cell receptor (TcR)/CD3-induced signal transduction by a mechanism that requires the interaction of CD4 with p56lck tyrosine kinase (Veillette et al.; Nature 1989 338:257). Here, we demonstrate that in the absence of TcR signaling, heat-inactivated HIV-1 (HIV-HI) also elicits a cascade of events generally considered to convey a positive signal, such as protein tyrosine phosphorylation, phosphatidylinositol 4-kinase and mitogen-activated protein kinase activation. These results contribute to understand better the control that HIV may exert on its own replication or on T cell apoptosis by modulating the activation status of its target cells through its interaction with T cell surface CD4 molecules.

References

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Citations

Aug 6, 1998·Journal of Biomedical Science·N Coudronnière, C Devaux
Mar 27, 2001·Transplantation Proceedings·D CrenesseJ Gugenheim
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Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D CrenesseA Schmid-Alliana
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May 15, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger RezzonicoHeidy Schmid-Antomarchi
Oct 30, 2003·Antiviral Chemistry & Chemotherapy·Mariko NakamuraTsuneya Ohno

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