HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction

The Journal of Infectious Diseases
Malin Holm Meyer-MyklestadDag Henrik Reikvam

Abstract

HIV-infected immunological non-responders (INR) fail to reconstitute their CD4 + T cell pool after initiation of antiretroviral therapy, and their prognosis is inferior to the immunological responders (IR). A prevailing hypothesis is that the INR phenotype is caused by a persistently disrupted mucosal barrier, but assessments of gut mucosal immunology in different anatomical compartments are scarce. We investigated circulating markers of mucosal dysfunction, immune activation, mucosal Th17 and Th22 cells, and mucosa-adherent microbiota signatures in gut mucosal specimens from sigmoid colon and terminal ileum of 19 INR and 20 IR in addition to 20 HIV negative individuals. INR had higher blood levels of the enterocyte damage marker Intestinal fatty acid binding protein (I-FABP) than IR. In gut mucosal biopsies, INR had lower fractions of CD4 + T cells, higher fractions of IL-22, and a tendency to higher fractions of IL-17 producing CD4 + T cells. These findings were all restricted to the colon and correlated to circulating markers of enterocyte damage. There were no observed differences in gut microbial composition between INR and IR. Restricted to the colon, enterocyte damage and mucosal immune dysfunction play a role for insuff...Continue Reading

References

Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gilbert R KaufmannUNKNOWN Swiss HIV Cohort Study
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard D Moore, Jeanne C Keruly
Jul 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth A LichtensteinUNKNOWN HIV Outpatient Study (HOPS) Investigators
Jan 22, 2011·The Journal of Infectious Diseases·Netanya G SandlerUNKNOWN INSIGHT SMART Study Group
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Sep 16, 2011·The Journal of Infectious Diseases·Michael M LedermanBenigno Rodriguez
Jul 12, 2013·Science Translational Medicine·Ivan Vujkovic-CvijinJoseph M McCune
Oct 31, 2013·Expert Review of Clinical Immunology·Marta MassanellaJulià Blanco
Apr 24, 2014·The Journal of Infectious Diseases·Peter W HuntMichael M Lederman
Sep 23, 2014·Nature Reviews. Immunology·Allan M Mowat, William W Agace
Dec 17, 2014·PLoS Pathogens·Alexandra SchuetzUNKNOWN RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups
Feb 9, 2016·AIDS·Christina M RamirezPeter W Hunt
Apr 15, 2016·EBioMedicine·Marc Noguera-JulianRoger Paredes
Sep 15, 2016·The Journal of Infectious Diseases·Joseph C Mudd, Jason M Brenchley
Sep 16, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Birgitte StiksrudAnne M Dyrhol-Riise
Mar 16, 2017·European Journal of Immunology·Kilian EyerichAndrea Cavani
Oct 14, 2017·Current Opinion in HIV and AIDS·Sandra Pinto-CardosoGustavo Reyes-Terán
Jan 10, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ilaria De BenedettoAlessandra Bandera
Mar 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yoshikazu MutohShinichi Oka
Jun 17, 2018·Mucosal Immunology·Tiffany Hensley-McBainNichole R Klatt
Jul 24, 2018·Frontiers in Microbiology·Wei LuBaoli Zhu
Mar 25, 2019·Frontiers in Immunology·Pushpa PandiyanJochen Huehn
May 1, 2019·Current HIV/AIDS Reports·Ivan Vujkovic-Cvijin, Ma Somsouk
Sep 11, 2019·The Journal of Infectious Diseases·Stéphane IsnardUNKNOWN Montreal Primary HIV Infection Study, the Canadian Cohort of HIV+ Slow Progressors, and the Canadian HIV and Aging Cohort Gr
Jan 3, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marco GelpiMarius Trøseid

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