PMID: 8941668Dec 1, 1996Paper

HIV-infected Langerhans cells constitute a significant proportion of the epidermal Langerhans cell population throughout the course of HIV disease

The Journal of Investigative Dermatology
C C ComptonK B Nadire

Abstract

Human immunodeficiency virus (HIV) is known to infect Langerhans cells, but controversy still exists about the occurrence of HIV-infected Langerhans cells in the skin of HIV-infected individuals and about the density of epidermal Langerhans cells during the course of HIV disease. In this study, epidermal Langerhans cell population densities were analyzed quantitatively in serial biopsies from two burn patients acquired over an 11-y period following infection with HIV from transfusions received during their acute treatment. At each biopsy time point, the density of epidermal Langerhans cells and the proportion that were infected with HIV were analyzed by immunostaining. In both patients, skin grafts were slow to repopulate with Langerhans cells and did not attain normal Langerhans cell densities until about 2 y after grafting. Thereafter, Langerhans cell densities remained within normal limits with the exception of six biopsies at random times that showed a supernormal number of epidermal Langerhans cells. HIV-infected Langerhans cells were first detected at about 2 y post-infection and comprised about one-third of the Langerhans cell population. At subsequent times, HIV p24-stained Langerhans cells were identified in most biops...Continue Reading

Citations

Dec 18, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L BhoopatT Bhoopat
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·I SimonitschW Jurecka
Aug 3, 2013·Reviews in Medical Virology·Andrew N HarmanPaul U Cameron
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia N RennRobert L Modlin
Dec 14, 1999·Journal of Medical Virology·P U CameronS M Crowe
Apr 27, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C G GalhardoE N Sarno
Jan 4, 2017·Reviews in Medical Virology·Rachel A BottingAndrew N Harman
Dec 28, 2018·Dermatologic Therapy·Manuela CeccarelliClaudio Guarneri
Oct 5, 2012·Development·Nousheen IramAdelheid Elbe-Bürger

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