HIV infection and bone mineral density in middle-aged women

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Julia H ArnstenEllie E Schoenbaum

Abstract

Osteopenia is prevalent in persons with human immunodeficiency virus (HIV) infection and is part of a normal sequence of aging in women. Most studies of bone mineral density (BMD) and HIV infection have focused on men or have lacked a comparison group of individuals without HIV infection with similar behavioral risk factors. We analyzed BMD in 495 middle-aged women (defined as women > or =40 years of age); 263 women had HIV infection, and 232 women were HIV-negative with behavioral risk factors similar to those of the HIV-positive group. The median age of the women in the study was 44 years, 54% were black, and 92% had used illicit drugs. Femoral neck BMD and lumbar spine BMD were reduced in women with HIV infection, compared with women without HIV infection (femoral neck BMD, 1.01+/-0.13 g/cm2 vs. 1.05+/-0.13 g/cm2; P=.001; lumbar spine BMD, 1.21+/-0.17 g/cm2 vs. 1.24+/-0.17 g/cm2; P=.04). In addition to HIV infection, other factors independently associated with lower BMD in both sites were being older, not being black, and having a low body weight. In race-stratified multivariate analyses, HIV infection was associated with BMD only in non-black women. Among HIV-positive women, 84% had taken antiretrovirals, and 62% had taken ...Continue Reading

References

Oct 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D E MeierB Catherwood
Aug 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Nov 1, 1987·The Journal of Clinical Investigation·C SlemendaC C Johnston
Jan 1, 1985·Epidemiologic Reviews·S R CummingsK J O'Dowd
Jun 1, 1983·American Journal of Epidemiology·W WillettC H Hennekens
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A C LookerR L Lindsay
Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Nov 1, 1994·The American Journal of Psychiatry·U SchweigerI Heuser
Oct 17, 1996·The New England Journal of Medicine·D MichelsonP Gold
Dec 24, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J CofrancescoA S Dobs
Sep 29, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P LipsI Wiklund
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Rizzoli, J P Bonjour
Sep 8, 2001·AIDS·A L MooreM A Johnson
Dec 13, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·S Loiseau-PérèsC L Benhamou
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kristin MondyPablo Tebas
Jun 12, 2003·The Journal of Infection·J TeichmannR G Bretzel
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fabio VesciniRenata Caudarella
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C AmielM C De Vernejoul
Apr 20, 2004·AIDS·Sara E DolanSteven Grinspoon
Jul 14, 2004·JAMA : the Journal of the American Medical Association·Joel E GallantUNKNOWN 903 Study Group
Oct 30, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S LandonioG M Vigevani
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea A HowardEllie E Schoenbaum
May 10, 2005·Menopause : the Journal of the North American Menopause Society·Samantha A MillerEllie E Schoenbaum

❮ Previous
Next ❯

Citations

Mar 9, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Michael YinElizabeth Shane
Dec 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S JonesM J Keller
Jun 30, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E M SteinE Shane
May 31, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M HamillA Prentice
Jun 1, 2006·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Rakhi KohliHenry S Sacks
Apr 25, 2012·Current HIV/AIDS Reports·Aoife G Cotter, Patrick W G Mallon
Dec 1, 2011·Sexual Health·Aoife G Cotter, Patrick W G Mallon
Dec 1, 2011·Sexual Health·Damien V Cordery, David A Cooper
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael T Yin, Marshall J Glesby
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa M ChirchRoy Steigbigel
Sep 16, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace A McComseyTodd T Brown
Dec 26, 2008·AIDS Research and Human Retroviruses·M RodríguezG K Robbins
Oct 31, 2009·British Medical Bulletin·Emily PollockEffrossyni Gkrania-Klotsas
Sep 1, 2009·Journal of Addiction Medicine·Theresa W KimJeffrey H Samet
Apr 7, 2007·AIDS·Karina M BergJulia H Arnsten
Jan 16, 2008·AIDS·Charles CazanaveUNKNOWN Groupe d'Epidémiologie Clinique du SIDA en Aquitaine
Nov 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael T YinKathryn Anastos
Jul 3, 2008·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Michael T YinElizabeth Shane
Nov 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael T YinElizabeth Shane
Mar 2, 2011·PloS One·Julie A WomackUNKNOWN Veterans Aging Cohort Study Project Team
Sep 24, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J L CasadoS Moreno
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Juliet Compston
Oct 11, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Denise L JacobsonIra B Wilson
Feb 9, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kristine M ErlandsonThomas B Campbell
Feb 10, 2011·Substance Use & Misuse·Robert S Klein
Oct 29, 2013·Enfermedades infecciosas y microbiología clínica·UNKNOWN Panel de expertos de GeSIDA y Plan Nacional sobre el Sida
Jun 6, 2007·Clinical Endocrinology·Mark J BollandIan R Reid
Nov 5, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Lauro F S Pinto NetoAngelica E Miranda
Sep 29, 2009·Maturitas·Nanette SantoroEllie Schoenbaum
Nov 26, 2008·The American Journal of Medicine·Clifford P MartinStephen A Klotz
Jan 15, 2008·The Journal of the Association of Nurses in AIDS Care : JANAC·Maithe EnriquezJacki Witt
Mar 2, 2011·Drug and Alcohol Review·Kenneth M Dürsteler-MacFarlandRudolf Stohler
Oct 20, 2010·Addiction·Andrew GreyIan R Reid
Jul 25, 2006·Drug and Alcohol Dependence·Theresa W KimJeffrey H Samet
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Mark J BollandIan R Reid
Oct 26, 2007·Pain·Glenda Gray, Phyllis Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.