HIV infection and dementia in older adults

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
V Valcour, Robert Paul

Abstract

Human immunodeficiency virus (HIV) infection in older patients is becoming increasingly common as seropositive individuals live longer because of long-term antiretroviral treatment. Simultaneously, the development and expression of dementia among HIV-infected patients is evolving in the era of highly active antiretroviral therapy (HAART) and immune reconstitution. How long-term HAART interacts with chronic HIV infection and advanced age with regard to cognition is not fully understood. This article provides an overview of HIV cognitive impairment as it relates to aging and presents some emerging issues in the field. Particular emphasis is placed on describing the changing landscape of HIV-related cognitive impairment and discussing possible concerns regarding the long-term effects of antiretroviral treatment. A brief discussion of potential adjunctive therapies to reduce cognitive symptoms associated with HIV infection in older individuals is provided.

References

Jan 23, 1995·Archives of Internal Medicine·W el-Sadr, J Gettler
Sep 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P R MeylanF Spertini
Jun 1, 1997·Mechanisms of Ageing and Development·W H AdlerJ E Nagel
Oct 6, 1997·Archives of Neurology·A I QureshiM R Frankel
Feb 26, 2000·Science·S Gartner
Mar 16, 2000·Seminars in Neurology·J C McArthurO Selnes
Dec 6, 2000·Journal of Psychopharmacology·J R Berger, G Arendt
Feb 13, 2001·Neurology·N SacktorUNKNOWN Multicenter AIDS Cohort Study
Oct 2, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·V TozziG Ippolito
Dec 26, 2001·Journal of Clinical Epidemiology·K GoodkinC Eisdorfer
Jan 5, 2002·Nihon rinsho. Japanese journal of clinical medicine·K Ohyashiki
Mar 23, 2002·Microbes and Infection·Diane M Lawrence, Eugene O Major
Apr 23, 2003·Journal of Neurovirology·Justin C McArthurNed Sacktor
Jul 11, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Diane Zablotsky, Michael Kennedy
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen A Wendel, Justin C McArthur
Nov 25, 2003·The New England Journal of Medicine·Nina Friis-MøllerUNKNOWN Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group
Apr 28, 2004·Neurology·M R WattersV G Valcour
May 19, 2004·Journal of the International Neuropsychological Society : JINS·Robert K HeatonUNKNOWN HNRC Group
Jun 19, 2004·AIDS Care·D A MurphyW N Steers
Aug 5, 2004·Annals of Neurology·Linda ChangThomas Ernst
Aug 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric R AndersonHuangui Xiong
Aug 19, 2004·AIDS·A d'ArminioUNKNOWN Writing Committee of the D:A:D: Study Group
Dec 8, 2004·Journal of Neuroimmunology·Ned SacktorAvindra Nath
Dec 8, 2004·Journal of Neuroimmunology·V ValcourN Sacktor
Dec 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Victor G ValcourNed C Sacktor
Jan 1, 2005·AIDS·Bruce ShiramizuVictor Valcour
Jan 5, 2005·Nature Reviews. Immunology·Francisco González-Scarano, Julio Martín-García
Jan 11, 2005·Neurotoxicity Research·Huanyu DouHoward E Gendelman
Jan 12, 2005·The Journal of Clinical Psychiatry·Judith G RabkinStephen J Ferrando
Jan 26, 2005·AIDS·Hans C Rempel, Lynn Pulliam

❮ Previous
Next ❯

Citations

Sep 25, 2010·AIDS and Behavior·J Cobb ScottUNKNOWN HIV Neurobehavioral Research Center (HNRC) Group
May 9, 2009·Neuropsychology Review·Lucette A Cysique, Bruce J Brew
Mar 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ari S NowacekHoward E Gendelman
Feb 18, 2011·International Psychogeriatrics·Emanuela Torreão Brito e SilvaGisele Rodrigues Fonseca Sagawa
May 23, 2012·International Psychogeriatrics·Sérgio Murilo Maciel Fernandes Filho, Heloísa Ramos Lacerda de Melo
Dec 15, 2010·Journal of the International Neuropsychological Society : JINS·Victor ValcourCecilia Shikuma
May 18, 2011·Neuropsychology·Erin E MorganUNKNOWN HIV Neurobehavioral Research Program (HNRP) Group
Aug 10, 2010·Journal of Clinical and Experimental Neuropsychology·April D ThamesCharles H Hinkin
Mar 3, 2009·JAAPA : Official Journal of the American Academy of Physician Assistants·Jeffrey D Myers
Sep 19, 2008·Menopause : the Journal of the North American Menopause Society·Délio Marques CondeAarão M Pinto-Neto
Aug 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gustavo D LopardoLidia I Cassetti
Aug 11, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erin E MorganUNKNOWN HIV Neurobehavioral Research Program (HNRP) Group
May 12, 2010·HIV Medicine·L A CysiqueB J Brew
Jul 4, 2009·Nanomedicine·Ari Nowacek, Howard E Gendelman
May 31, 2012·Journal of Neurovirology·Crystal C Watkins, Glenn J Treisman
Jun 7, 2011·Brain Research·Marianne StrazzaMichael R Nonnemacher
Jan 16, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wen HuangMichal Toborek
Nov 26, 2008·The American Journal of Medicine·Clifford P MartinStephen A Klotz
Jul 17, 2007·Clinics in Geriatric Medicine·Vera P Luther, Aimee M Wilkin
Jan 1, 2007·Progress in Polymer Science·A V Kabanov, H E Gendelman
Dec 29, 2007·The Journal of Pathology·V Appay, D Sauce
Dec 14, 2011·Brain Pathology·Christine Lund KraghEliezer Masliah
Oct 13, 2011·Reviews in Medical Virology·María del PalacioM Ángeles Muñoz-Fernández
Sep 1, 2015·Neurochemistry International·Rajat SandhirNitin Singhal
May 29, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Sandra Wagner CardosoBeatriz Grinsztejn
Oct 30, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Cezar Arthur Tavares PinheiroRicardo Tavares Pinheiro
Nov 10, 2007·Clinical Nursing Research·Kathleen M Nokes, Peter C Nwakeze
Oct 19, 2016·Biomaterials Science·Arti VashistMadhavan Nair
Apr 27, 2011·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Maria FrontiniRebecca A Clark
Oct 14, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Savanna TierneyRodrigo Hasbun
May 26, 2018·AIDS·Minjie WuUNKNOWN Neuropsychology Working Group of the Multicenter AIDS Cohort Study
Jul 24, 2020·AIDS·Kirsten BobrowKristine Yaffe
Feb 23, 2019·Journal of Neurovirology·Miroslaw Mack MackiewiczEliezer Masliah
Oct 30, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anika GuhaBeau M Ances
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Jason D FlattMark Brennan-Ing
May 18, 2018·JCI Insight·Jeffrey E TeiglerUNKNOWN RV254/RV217 study groups
Dec 15, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zikhona Gabazana, Lungile Sitole

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