Abstract
The role of HIV infection in precipitating different clinical features in cryptococcal meningitis (CM) patients remains controversial. One hundred twelve CM patients living with HIV/AIDS (CM+HIV+ patients) and 112 CM patients living without HIV/AIDS (CM+HIV- patients) were enrolled after propensity score matching. Demographic characteristics, symptoms, routine blood tests, and biochemical and cerebrospinal fluid (CSF) profiles were compared between the two groups. Kaplan-Meier analysis and Cox proportional hazards model was used to assess 10-week mortality. CM+HIV+ patients frequently occurred in young (mean age 40.3 ± 10.5) and male (89.3%) populations who also experienced leukopenia, neutropenia, lymphocytopenia, thrombocytopenia, and hypoalbuminemia, less headaches (66.9%), and higher cryptococcemia (23.2%) (all p < .050); they also had higher glucose (2.6 ± 1.1 mmol/L), increased smear positivity (78.8%), and decreased white blood cells [8.0 (2.0-28.0) × 106/L] in initial CSF assay (all p < .050). The 10-week cumulative survival rate was 84.6% for CM+HIV+ patients and 88.5% for CM+HIV- patients (p = .345). Age <35.0 years (hazard ratio (HR) 3.0 (1.0-8.9), p = .046), intracranial pressure (ICP) >250.0 mmH2O (HR: 4.8 (1.1-21....Continue Reading
References
Jun 3, 2004·Lancet·Annemarie E BrouwerThomas S Harrison
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G Pappas
Mar 13, 2009·AIDS·Tihana BicanicThomas Harrison
Jan 6, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectTania C Sorrell
Apr 16, 2010·Medical Mycology·Li-Ping ZhuXin-Hua Weng
Apr 29, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yi-Chien LeeYee-Chun Chen
May 20, 2011·The Journal of Infectious Diseases·Xue-Ting OuXin-Hua Weng
May 23, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Hung LiaoJen-Hsian Wang
Oct 11, 2013·The Lancet Infectious Diseases·Lei ZhangDavid P Wilson
Apr 22, 2014·Reumatología clinica·Ramiro F TrillosJuan M Gutiérrez
May 30, 2014·Clinical Epidemiology·Derek J Sloan, Victoria Parris
Oct 18, 2014·Neurological Research·Alejandra Gonzalez-DuarteJesús Higuera-Calleja
Dec 3, 2014·Fungal Genetics and Biology : FG & B·Wei FangWanqing Liao
Oct 22, 2016·BMC Infectious Diseases·Songyuan TangJoseph D Tucker
Nov 23, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ian GassiepElliott G Playford
Nov 26, 2016·Nature Reviews. Neurology·Peter R WilliamsonThomas S Harrison
Jan 31, 2017·Bioscience Trends·Yongjia JiHongzhou Lu
May 10, 2017·The Lancet Infectious Diseases·Radha RajasinghamDavid R Boulware
Aug 5, 2017·The Lancet Infectious Diseases·Andrew H LimperThomas S Harrison
Sep 1, 2017·Mycoses·Yingfang LiWeihua Pan
Mar 23, 2018·The Tohoku Journal of Experimental Medicine·Wenwen PangXiaofang Pei
Jan 19, 2019·Medical Mycology·Lijun XuYan Xu
Jan 25, 2019·Infectious Diseases·Lijun XuYan Xu