HIV Infection, hepatitis C infection, and HAART: hard clinical choices

JAMA : the Journal of the American Medical Association
Shyam KottililJoseph A Kovacs

Abstract

Abnormalities in hepatic function have become one of the most common complications occurring among human immunodeficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART), and liver disease has become an increasingly important cause of morbidity and mortality in HIV-infected patients. We present a case of a patient with HIV infection and hepatotoxicity that exemplifies the complications currently observed during the treatment of such patients. Hepatotoxicity can be a result of several factors, including a direct effect of HAART, substance abuse, and coinfection with either hepatitis C virus (HCV) or hepatitis B virus. Imaging studies may be helpful in determining the etiology; however, a liver biopsy is often necessary to be able to more accurately determine the relative contributions of different processes. Although coinfection with HCV and HIV has become a common clinical problem, optimal treatment of such patients remains to be defined and must be individualized to maximize benefit and tolerance.

Citations

Feb 25, 2005·Current Infectious Disease Reports·Benigno Rodriguez, David A Bobak
Apr 24, 2010·Emergency Medicine Clinics of North America·Daniel M LugassyLewis S Nelson
Mar 25, 2008·Annals of Emergency Medicine·Arvind VenkatCory P Heidelberger
Jan 13, 2006·Gastroenterology·Jules L Dienstag, John G McHutchison
Apr 12, 2014·AIDS Care·Marco PereiraMaria Cristina Canavarro
Aug 11, 2016·Journal of Behavioral Medicine·Marco Pereira, Renata Fialho
Mar 2, 2006·The Annals of Pharmacotherapy·Christine A Hughes, Stephen D Shafran
Jul 6, 2021·Journal of Clinical and Translational Hepatology·Sandeep SatsangiParul Kodan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.