HIV infection, hypercoagulability and ischaemic stroke in adults at the University Teaching Hospital in Zambia: a case control study

BMC Infectious Diseases
Stanley ZimbaMasharip Atadzhanov

Abstract

In Zambia, 14.2% of adults have HIV/AIDS. There has been a substantial and significant increase in patients hospitalized for ischaemic stroke with co-existing HIV infection. However, little is known about the mechanism of stroke in these HIV + ve patients let alone studied in our region. The aim of this pilot study was to explore the association of hypercoagulability state in HIV + ve patients with ischaemic stroke. This was achieved by comparing hypercoagulability state markers between HIV + ve ischaemic stroke patients with HIV-ve and HIV + ve patients with and without ischaemic stroke respectively. A matched case control study in which a total of 52 HIV + ve patients with ischaemic stroke were prospectively compared with control groups for the presence of protein S, protein C deficiencies and hyperhomocysteinaemia. The control groups comprised an equal number of consecutively matched for age and sex HIV-ve and HIV + ve patients with and without ischaemic stroke respectively. Data was analysed in contingency tables using Paired t- test, Chi square and conditional logistic regression. Ischaemic stroke of undetermined aetiology occurred more frequently in HIV + ve compared to HIV-ve patients (p < 0.001). In addition, protein S ...Continue Reading

References

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Citations

Mar 17, 2018·AIDS·Kiran T ThakurGretchen L Birbeck
Sep 25, 2019·Journal of the American Heart Association·Thita ChiasakulAdam Cuker
Apr 15, 2020·African Journal of Disability·Tasneem HartleyGakeemah Inglis-Jassiem
Oct 20, 2020·European Stroke Journal·Jan H SchaeferWaltraud Pfeilschifter
Aug 8, 2018·Indian Journal of Medical Microbiology·Swati KhareUma Shankar Singh
Feb 9, 2020·Progress in Cardiovascular Diseases·Samson OkelloMark J Siedner
Jun 18, 2021·AIDS·Stanley ZimbaDeanna Saylor

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS ) statistics
TOAST

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