HIV infection is not associated with the initiation of curative treatment in women with cervical cancer in Botswana

Cancer
Surbhi GroverNicola M Zetola

Abstract

Cervical cancer is the leading cause of cancer death in Sub-Saharan Africa. The risk of developing cancer is increased for women living with human immunodeficiency virus (HIV) infection. It is unknown which factors predict the initiation of curative chemoradiotherapy (CRT) in resource-limited settings and whether HIV is associated with initiating curative CRT in settings with a high HIV burden. All women living with and without HIV infection who were initiating curative and noncurative CRT for locally advanced cervical cancer in Botswana were prospectively enrolled in an observational study. The factors associated with receiving CRT were evaluated in all patients and the subgroup of women living with HIV. Of 519 enrolled women, 284 (55%) initiated CRT with curative intent. The curative cohort included 200 women (70.4%) who were living with HIV and had a median CD4 count of 484.0 cells/μL (interquartile range, 342.0-611.0 cells/μL). In the noncurative cohort, 157 of 235 women (66.8%) were living with HIV and had a median CD4 count of 476.5 cells/μL (interquartile range, 308.0-649.5 cells/μL). HIV status was not associated with initiating curative CRT (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.58-1.56). The factors a...Continue Reading

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Citations

Feb 26, 2019·Cancer·Richard F Little
Oct 25, 2020·The Laryngoscope·Gwendolyn J McGinnisSurbhi Grover
Jun 9, 2021·JCO Global Oncology·Samarpita MohantySurbhi Grover
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Sep 9, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Emily MacDuffieSurbhi Grover

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